同济大学学报（医学版）2018，Vol.39Issue(2)：94-98,5.DOI:10.16118/j.1008-0392.2018.02.018
HE4与慢性心力衰竭患者心功能的相关性
Correlation between HE4 and cardiac function in chronic heart failure patients
摘要
Abstract
Objective To investigate the relationship between human epididymis protein 4(HE4)level and cardiac function in chronic heart failure patients. Methods Two hundred patients aged 71.81±12.49 years with chronic heart failure admitted in hospital were enrolled in the study.Patient were divided into low risk heart failure group(gradeⅠ-Ⅱ)and high risk heart failure group(gradeⅢ-Ⅳ). The risk factors of chronic heart failure were analyzed with Logistic regression.Results There were no significant differences in BMI and HDL-c between two groups(P≥0.05), while there were significant differences in LDL-C, CRP,HE4 and UA between two groups(P<0.05). HE4 and NT-proBNP were independent risk factors for predicting cardiac insufficiency. The gender, HE4 level and NT-proBNP were independent risk factors of cardiac dysfunction when age,sex,HE4,NT-proBNP,smoking,drinking,HDL-C,LDL-C and UA were adjusted. Conclusion Gender, HE4 and NT-proBNP are independent risk factors of cardiac insufficiency,and HE4 levels are associated with the classification of cardiac function in chronic heart failure patients.关键词
人附睾蛋白(human epididymis protein 4,HE4)/慢性心力衰竭/危险因素Key words
human epididymis protein 4/chronic heart failure/risk factor分类
医药卫生引用本文复制引用
曹建红,刘怡,唐荣萍,徐春华,兰琴,范慧敏..HE4与慢性心力衰竭患者心功能的相关性[J].同济大学学报（医学版）,2018,39(2):94-98,5.基金项目
上海市卫计委课题(201440046) （201440046）
同济大学附属东方医院朝阳人才计划(DFZY-17) （DFZY-17）
