世界中医药2018，Vol.13Issue(4)：869-873,5.DOI:10.3969/j.issn.1673-7202.2018.04.021
益气固本祛瘀汤联合血管紧张素受体阻滞剂防治糖尿病心肌病患者心室重构的疗效及对血液流变学、TGF-β、TNF-α、VEGF的影响
Clinical Observation on Yiqi Guben Quyu Decoction Combined with Angiotensin Receptor Blocker(ARB) in Prophylaxis and Treatment of Ventricular Remodeling on Patients with Diabetic Cardiomyopathy
摘要
Abstract
Objective:To observe the effects of Yiqi Guben Quyu Decoction combined with angiotensin receptor blocker(ARB)on prophylaxis and treatment of ventricular remodeling in patients with diabetic cardiomyopathy(DCM)and its effects on hemorheolo-gy,serum transforming growth factor-β(TGF-β), tumor necrosis factor-α(TNF-α)and vascular endothelial growth factor (VEGF).Methods:A total of 140 patients with DCM were divided into observation group(70 cases)and control group(70 ca-ses)according to the random number table admitted and treated in Yan'an Hospital of TCM from November 2014 to November 2016.Both groups of patients were given conventional basic therapy.The control group patients were treated with telmisartan tab-lets(80 mg /time,1 time /day)on the basis of conventional basic therapy,and the observation group patients were treated on the basis of the control group by self-made Yiqi Guben Quyu Decoction.Patients of both groups were treated for 6 months;cardiac ul-trasonography and electrocardiography related indexes of the two groups before treatment,3 months and 6 months after treatment were observed;The incidence rate of ventricular remodeling of different sexes of the two groups before treatment,3 months and 6 months after treatment was caculated.Blood rheology,serum TGF-β, TNF-αand VEGF levels were measured at the above time points.Results:The levels of LVEF,LVEDD,LVESD,LVMI,SDNN,SDANN,SDNN5 and rMSSD were significantly improved in the observation group after 3 months'and 6 months'treatment.The improvement of the above indexes was better than those of the control group(P<0.05); The incidence rates of ventricular remodeling were significantly lower in the two groups after 3 months'and 6 months'treatment(P<0.05); The improvement of patients in the observation group was better than that in the control group(P<0.05); Whole blood viscosity, plasma viscosity, fibrinogen, erythrocyte aggregation index, serum TGF-β, TNF-αand VEGF levels were significantly lower in the two groups after treatment.The above indexes were lower than those in the control group(P<0.05).Conclusion:Yiqi Guben Quyu Decoction combined with ARB can significantly improve ventricular re -modeling and electrical remodeling and improve myocardial function in DCM patients.The mechanism may be related to the im-provement of hemorheology and the inhibition of serum TGF-β,TNF-αand VEGF expression.关键词
益气固本祛瘀汤/血管紧张素受体阻滞剂/糖尿病心肌病/心室重构/血液流变学Key words
Yiqi Guben Quyu decoction/Angiotensin receptor blockers/Diabetic cardiomyopathy/Ventricular remodeling/He-morheology分类
医药卫生引用本文复制引用
张晶,马强,陈荣..益气固本祛瘀汤联合血管紧张素受体阻滞剂防治糖尿病心肌病患者心室重构的疗效及对血液流变学、TGF-β、TNF-α、VEGF的影响[J].世界中医药,2018,13(4):869-873,5.基金项目
陕西省卫生厅医学联合基金项目(2015211C209) （2015211C209）
