世界中医药2018，Vol.13Issue(4)：893-896,4.DOI:10.3969/j.issn.1673-7202.2018.04.027
真武汤加减对心肾阳虚型慢性心力衰竭细胞黏附分子表达及其对心脏结构和功能的影响
Effect of Modified Zhenwu Decoction on Expression of Cell Adhesion Molecule,Cardiac Structure and Function in Chronic Heart Failure Patients Due to Heart Kidney Yang Deficiency
摘要
Abstract
Objective:To study the effects of modified Zhenwu Decoction on expression of cell adhesion molecule, cardiac struc-ture and function in chronic heart failure patients due to heart kidney yang deficiency.Methods:A total of 90 cases of chronic heart failure patients due to heart kidney yang deficiency in our hospital during September 2014 to January 2017 were randomly divided into control group and study group according to the random number table method,with 45 cases in each group.Patients in control group were treated with routine Western medicine treatment, and those in study group were treated with Zhenwu decoction com-bined with conventional western medicine.The treatment lasted for one month.The levels of serum soluble cell adhesion molecule-1(sICAM-1),cardiac structural parameters and cardiac function parameters were compared before and after treatment between two groups.Results:Before treatment,there was no significant difference in serum sICAM-1 content, ultrasonic cardiac structural pa-rameters,and cardiac function parameters between two groups(P>0.05).One month after treatment,serum content of sICAM-1 in study group was lower than that in control group(P<0.05); cardiac structure parameters such as LVESD, LVEDD, IVS, LVPW in study group were lower than those in control group(P<0.05);cardiac function parameters such as LVEF,SV,CO in study group were higher than those in control group(P<0.05).Conclusion:Chronic heart failure patients due to heart kidney yang deficiency receives Zhenwu decoction combined with western medicine treatment,can effectively inhibit the expression of ad-hesion molecules,and optimize cardiac structure and function.关键词
心肾阳虚型/慢性心力衰竭/真武汤/细胞黏附分子/心脏结构/左心室收缩末内径/心功能/左心室射血分数/心输出量Key words
Chronic heart failure due to heart kidney yang deficiency/Zhenwu Decoction/Cell adhesion molecule/Cardiac structure/Left ventricular end systolic diameter/Heart function/Left ventricular ejection fraction/Cardiac output分类
医药卫生引用本文复制引用
耿振平,陈阳春..真武汤加减对心肾阳虚型慢性心力衰竭细胞黏附分子表达及其对心脏结构和功能的影响[J].世界中医药,2018,13(4):893-896,4.基金项目
河南省卫生厅2014年卫生政策研究课题计划(YWZY201403) （YWZY201403）
