世界中医药2018，Vol.13Issue(4)：940-943,4.DOI:10.3969/j.issn.1673-7202.2018.04.037
黄芪注射液与葛根素注射液联用对2型糖尿病小鼠心脏损害的干预作用
Effects of Astragalus Injection Conjunction with Puerarin Injection on Cardiac Injury in Mice with Type 2 Diabetes Mellitus
摘要
Abstract
Objective:To observe the effects of astragalus injection combined with puerarin injection on diabetic heart damage,and to lay a foundation for further study of its mechanism.Methods:Male KKAy mice(n=60)were fed with high fat diet to establish type 2 diabetes mellitus.Male C57BL/6J mice(n=30)with the same age were included into normal group.Mice with 12 weeks of age were randomly divided into treatment group and model group.The KKAy mice were injected with astragalus injection and puera-rin injection or the same amount of normal saline.After feeding at 8th,12th and 16th weeks,the general signs of mice were ob-served to detect the levels of the fasting blood glucose(FBG),serum triglyceride(TG),and total cholesterol(TCHO).The mor-phological myocardial tissue was observed,and TUNEL method was used to detect the level of apoptosis.Results:Astragalus injec-tion combined with puerarin injection could improve the symptoms of type 2 diabetes mellitus,slow activity,significant increase in urine output,lack of luster of body hair,body fat and other symptoms.After 6 weeks and 12 weeks treatment,it can significantly re-duce FBG,TG and TCHO(P<0.05),reduce myocardial cell apoptosis,improve myocardial fibrosis,but 16 weeks treatment was not significantly effective.Conclusion:The use of astragalus injection and puerarin injection can significantly improve the general state of type 2 diabetic mice,reduce FBG,TG and TCHO,inhibit myocardial cell apoptosis and reduce cardiac fibrosis.关键词
黄芪注射液/葛根素注射液/糖尿病/心脏损害/KKAy小鼠Key words
Astragalus injection/Puerarin injection/Diabetic cardiac injury/Diabetic heart injury/KKAy mice分类
医药卫生引用本文复制引用
李奕萱,王谦,王岩飞,李姝玉,刘朝霞,张达,赵福建,张淑静,高誉珊,赵淑英..黄芪注射液与葛根素注射液联用对2型糖尿病小鼠心脏损害的干预作用[J].世界中医药,2018,13(4):940-943,4.基金项目
北京高等学校青年英才计划(YETP0794) （YETP0794）
北京中医药大学创新团队项目(2011-CXD-04) （2011-CXD-04）
