世界中医药2018，Vol.13Issue(4)：954-958,5.DOI:10.3969/j.issn.1673-7202.2018.04.040
多时间点观察电针"委中"对大鼠腰多裂肌损伤后IGF1R和IGFBP3的表达
Effects of Electro-acupuncture at Weizhong(BL 40)on the Expression of IGF1R and IGFBP3 in Rats with Multifidus Muscle Injury
摘要
Abstract
Objective:To observe the effects of electro-acupuncture at BL 40 on the expression of the type 1 IGF receptor (IGF1R)and IGF binding protein 3(IGFBP3)in rats with multifidus muscle injury.Methods:A total of 90 male Sprague Dawley rats were randomly divided into blank group(BG),model group(MG)and BL 40 electro acupuncture group(WG),with 30 rats in each group.Then the rats in MG and WG were injected with 0.5% bupivacaine into both sides of L 4-5multifidus muscle.After model establishment,the rats in WG accepted electro-acupuncture once a day.The changes of IGF1R and IGFBP3 in 3 groups' multifidus muscle were observed and analyzed at 1st,2nd,3rd,7th and 14th day.Results:The expression of IGF1R at day 2,3,7, 14 was higher than BG(P<0.05),while WG was higher than MG at day 1 and day 2.The MG's expression of IGFBP3 was higher than BG's at day 7 and day 14.Compared with MG,the expression of IGFBP3 in WG decreased at day 2 and day 14.Conclusion:Electro-acupuncture at BL 40 could increase the expression of IGF1R and decrease the expression of IGFBP3,so as to promote the regeneration of tissue after multifidus muscle injury.关键词
多裂肌/电针/委中/1型胰岛素样生长因子受体/胰岛素样生长因子结合蛋白3Key words
Electro-acupuncture/Multifidus muscle/BL 40/Type 1 IGF receptor/IGF binding protein 3分类
医药卫生引用本文复制引用
卢宗孝,张莉,霍则军,晏珺,于雪,陈冬荔,邹德辉,陈玉佩,许玥,张佳怡,白玉琢..多时间点观察电针"委中"对大鼠腰多裂肌损伤后IGF1R和IGFBP3的表达[J].世界中医药,2018,13(4):954-958,5.基金项目
国家自然科学基金项目(81574052) （81574052）
