世界中医药2018，Vol.13Issue(4)：993-996,4.DOI:10.3969/j.issn.1673-7202.2018.04.049
T抗氧化活性参与蒲公英对小鼠实验性胃溃疡的保护作用
Protective Effects of Dandelion on Ethanol-induced Gastric Ulcer in Mice through Antioxidant Activity
摘要
Abstract
Objective:To evaluate the protective effect of dandelion on ethanol induced gastric ulcer and investigate its possible mechanism in mice.Methods:A total of 50 mice were randomly divided into normal group,model group,dandelion high,medium and low dose groups [15,5,1.5 g/(kg· d)],with 10 mice in each group.Administration of dandelion prior to ethanol ingestion dose-dependently inhibited gastric ulcer.After 4 h modeling,the gastric mucosal lesion was assessed by ulcer area,and mucosal in-jury index and injury inhibition rates were calculated.The contents of malondialdehyde(MDA)and nitric oxide(NO)in serum were measured.The activity of superoxide dismutase(SOD)was also determined.Results:Compared with the control group,the mucosal injury index,contents of MDA and NO in serum were markedly increased in the model group(P<0.01),and the activity of SOD was significantly decreased in mice model with gastric ulcer(P<0.01).Compared with the model group,dandelion [15, 5 g/(kg· d)] significantly reduced the gastric ulcer index,raised the activity of SOD in serum(P<0.01 or P<0.05).In addi-tion,dandelion also significantly inhibited MDA and NO concentrations in serum in the mice exposed to ethanol induced ulceration (P<0.01 or P<0.05).Conclusion:Dandelion has good protective efficacy in treating ethanol induced gastric ulcer in mice.Its mechanism might be related to enhancing endogenous antioxidant capacity and inhibition of overproduction of NO.关键词
蒲公英/实验性胃溃疡/超氧化物歧化酶/丙二醛/一氧化氮Key words
Dandelion/ethanol-induced gastric ulcer/Superoxide dismutase/Malondialdehyde/Nitric oxide分类
医药卫生引用本文复制引用
张云,林凡..T抗氧化活性参与蒲公英对小鼠实验性胃溃疡的保护作用[J].世界中医药,2018,13(4):993-996,4.基金项目
福建省自然科学基金项目(2016J01389) （2016J01389）
福建省高等学校新世纪优秀人才支持计划项目 （）
