生物骨科材料与临床研究2018，Vol.15Issue(2)：5-8,后插1-后插2,6.DOI:10.3969/j.issn.1672-5972.2018.02.002
人工寰齿关节置换活体动物模型的建立及相关研究
An in vivo experimental study of a novel artificial atlanto-odontoid joint and related research
蔡璇 1李浩鹏 1董军 1黄思华 1贺西京1
作者信息
- 1. 西安交通大学第二附属医院骨二科,陕西 西安,710004
- 折叠
摘要
Abstract
Objective To establish an in vivo animal model of artificial atlanto-odontoid joint arthroplasty,explore suitable surgical methods and lay a theoretical foundation for subsequent clinical application.Methods The unconstrained artificial atlanto-odontoid joint for canines were designed and manufactured based on the anatomical data of 15 sets of normal atlantoaxial dry specimens from canines.18 healthy adult male mongrel canines were randomly divided into three groups:normal control group,prosthesis replacement group and Harms plate fusion fixation group.The operative time,blood loss,surgical complications,and postoperative recovery of experimental animals was compared by general observation and imaging examinations after surgery.Results Artificial atlanto-odontoid joint was easy to operate and does not cause side injury.Postoperative radiographs and three-dimensional CT showed that the prosthesis was in the correct position.The screws were located in the pre-designed screw passages,and there was no loosening of the prosthesis and compression of the spinal cord.The operative time,intraoperative blood loss and surgical recovery time were similar to those of Harms plate fusion and internal fixation group,and they also had significant advantages in preserving movement of the atlantoaxial complex.Conclusion The unconstrained artificial atlanto-odontoid joint prosthesis designed by us can be bionic on the atlantoaxial in terms of structure and function,achieving the dual purpose ofbalancing the stability and movement function of the atlantoaxial.This technique provides an option for surgical treatment ofatlantoaxial disorders,in line with the development trend of the cervical spine non-fusion technology.关键词
寰枢椎/人工寰齿关节/动物模型/非融合Key words
Atlantoaxial/Artificial atlanto-odontoid joint/Animal model/Nonfusion分类
医药卫生引用本文复制引用
蔡璇,李浩鹏,董军,黄思华,贺西京..人工寰齿关节置换活体动物模型的建立及相关研究[J].生物骨科材料与临床研究,2018,15(2):5-8,后插1-后插2,6.
