生殖医学杂志2018，Vol.27Issue(5)：400-405,6.DOI:10.3969/j.issn.1004-3845.2018.05.002
冻融胚胎囊胚培养中胚胎质量与囊胚形成之间关系
Relation of embryos quality and blastocyst formation in frozen-thawed embryos culture
陈希曦 1黎淑贞 1吴海涛 1黎平 1郭江华 1梁辉洪1
作者信息
- 1. 广东省江门市中心医院生殖中心,江门 529030
- 折叠
摘要
Abstract
Objective:To investigate the relationship of embryo quality and blastocyst formation in frozen-thawed embryos culture.Methods:The data of 449 patients conducting 478 frozen-thawed cycles in Jiangmen Center Hospital from 2013 to 2016 were retrospectively analyzed.The blastocyst formation rate,available blastocyst formation rate,and high-quality blastocyst formation rate of thawed blastocysts were compared according to age,survival status of thawed embryos,numbers and grade of Day 3 embryonic cells,and Day 3 embryo quality.The correlation of various factors with available/high quality blastocysts was analyzed.Results:The blastocyst formation rate,available blastocyst formation rate and good quality blastocyst formation rate were decreased along with age,but there was no significant difference(P＞0.05).The blastocyst formation rate,available blastocyst formation rate and good quality blastocyst formation rate in full-survival embryos group were significantly higher than those in semi-survival embryos group (P＜0.05).Those formation rate in good quality of Day 3 embryos group were significantly higher than nongood quality of Day 3 embryos group(P＜0.05),and the indicators of 7-9 cells embryos group &＞9 cells embryos group was significantly higher than＜7 cells embryos group(P＜0.05),as well as A+B grade good quality of Day 5 embryos group was better than C+D grade group(19.82％ vs.14.83％)(P＜0.05).The logistic results showed that patients' age,embryo survival status after thawing,number of Day 3 embryonic cells were significantly corrected with available blastocyst formation(P＜0.05).The patients' age,embryo survival status after thawing,number and grade of Day 3 embryonic cells were also significantly correlated with good quality blastocyst formation rate(P＜0.05).Conclusions:In frozen-thawed embryonic culture,the patients' age,embryos survival status after thawing,the number and grade of embryonic cells can significantly impact blastocyst formation and quality,in which survival status of embryos after thawing is the most predictive factor for available/good quality blastocyst formation.关键词
胚胎质量/囊胚/冻融胚胎移植Key words
Embryo quality/Blastocysts/Frozen-thawed embryo transfer引用本文复制引用
陈希曦,黎淑贞,吴海涛,黎平,郭江华,梁辉洪..冻融胚胎囊胚培养中胚胎质量与囊胚形成之间关系[J].生殖医学杂志,2018,27(5):400-405,6.
