天津中医药2018，Vol.35Issue(5)：397-400,4.DOI:10.11656/j.issn.1672-1519.2018.05.18
AMPK在保护血管功能中研究进展
Research progress of AMPK in protecting vascular function
摘要
Abstract
Adenosine monophosphate-activated protein kinase (AMPK)is a serine/threonine protein kinase and sensor of cellular energy status,which involved in the regulation of cellular and whole organ metabolism.Activation of AMPK has a number of potentially beneficial antiatherosclerotic effects including reducing adhesion of inflammatory cells to the blood vessel endothelium,reducing lipid accumulation and the proliferation of inflammatory cells caused by oxidised lipids,stimulation of gene expression responsible for cellular antioxidant defenses and stimulation of enzymes responsible for nitric oxide formation. In addition to drugs commonly used in cardiovascular and metabolic disease, such as statins, metformin and the TZDs, many of the TCM also involve the activation of AMPK. In general, the activation of AMPK is closely related to the maintenance of vascular health. This paper reviews the research progress of the role and mechanism of AMPK in the protection of vascular function.关键词
AMPK/血管功能/中医药Key words
AMPK/vascular function/traditional Chinese medicine分类
医药卫生引用本文复制引用
张洋,王利,曹爱丽,陈骏良,彭文,王浩..AMPK在保护血管功能中研究进展[J].天津中医药,2018,35(5):397-400,4.基金项目
上海市医学重点专科建设项目(ZK2015A18) （ZK2015A18）
普陀区高层次人才科研创新项目(2014-A-19). （2014-A-19）
