眼科新进展2018，Vol.38Issue(5)：444-447,4.DOI:10.13389/j.cnki.rao.2018.0103
视锥视杆细胞营养不良患者脉络膜和视网膜血流的异常变化
The anomalies of choroidal and retinal blood flow in cone-rod dystrophy
摘要
Abstract
Objective To study the alteration of blood flow indexes of ophthalmic artery (OA),central retinal artery (CRA) and posterior ciliary artery (PCA) of the patients with cone-rod dystrophy (CRD).Methods The color doppler flow imaging was used in 50 CRD patients (100 eyes,CRD group) and 90 controls (180 eyes,control group) to measure the peak systolic velocity (PSV),end diastolic velocity (EDV),timeaveraged maximum velocity (TAMV),pulsatility index (PI) and resistance index (RI)in OA,CRA and PCA,respectively,and the data was obtained and analyzed statistically by one-sample t test to compare the alteration of these parameters between the CRD group and control group.Results The TAMV of OA was (14.29 ±3.88)cm · s-1 in CRD group and (12.44 ± 3.64) cm · s-1 in the control group,and the difference was statistically significant (P ＜0.05);meanwhile,the PI was 1.75 ±0.42 in CRD group and 2.02 ±0.71 in the control group,and the difference was statistically significant (P ＜0.05).Moreover,the PSV,EDV,TAMV and PI,RI of CRA was (4.60 ± 1.29) cm · s-1,(1.61 ±0.41)cm · s-1,(2.59 ±0.67)cm · s-1 and 1.11 ±0.31,0.63 ±0.10 in CRD group,respectively,and (10.82 ± 2.97) cm · s-1,(3.28 ± 1.11) cm · s-1,(5.50 ± 2.06)cm · s-1 and 1.48 ±0.49,0.71 ±0.08,in the control group,accordingly,and the differences were statistically significant (all P ＜ 0.05).Furthermore,the PSV,EDV,TAMV and PI,RI of PCA was (7.36 ± 2.18) cm · s-1,(2.28 ± 0.82) cm · s-1,(3.99 ± 1.22)cm · s-1 and 1.28 ± 0.37,0.68 ± 0.09 in CRD group,respectively,and (11.61 ± 3.41)cm · s-1,(3.34±1.25)cm · s-1,(5.83 ±1.91)cm · s-1 and 1.49 ±0.43,0.70 ±0.09 in the control group,accordingly,and the differences were statistically significant (all P ＜0.05).Conclusion Hemodynamic unusual alterations of OA,CRA and PCA in CRD patients suggest there is the correlation between the ocular blood supply and the pathological process of CRD,which remains to be observed further.关键词
视锥视杆细胞营养不良/眼动脉/视网膜中央动脉/睫状后动脉/彩色多普勒血流成像Key words
cone-rod dystrophy/ophthalmic artery/central retinal artery/posterior ciliary artery/color doppler flow imaging分类
医药卫生引用本文复制引用
陶天畅,王蕾,崇伟华,张芷萌,代贺华,许静,李根林..视锥视杆细胞营养不良患者脉络膜和视网膜血流的异常变化[J].眼科新进展,2018,38(5):444-447,4.基金项目
国家自然科学基金资助(编号:81271046) （编号:81271046）
北京市自然科学基金项目暨北京市教育委员会科技发展计划重点项目(编号:KZ201510025025)National Natural Science Foundation of China (No:81271046) （编号:KZ201510025025）
Joint Program of Beijing Municipal Natural Science Foundation (Category B)& Beijing Educational Committee (Key Project) (No:KZ201510025025) （Category B）
