摘要
Abstract
Objective To investigate the relationship between the degree of diabetic retinopathy (DR) and renal function in patients with type 2 diabetes mellitus (T2DM).Methods Totally 189 cases of patients (189 eyes) with T2DM from January 2016 to October 2016 were enrolled in the study.According to the diagnostic criteria of DR,the patients were divided into non-DR group (NDR group,101 eyes) and DR group (88 eyes).And the patients in the DR group was subgrouped into mild non-proliferative DR (NPDR) group (31 eyes),moderate NPDR group (26 eyes),severe NPDR group (19 eyes) and proliferative DR (PDR) group (12 eyes) according to the severity.And the renal function related variables were detected,and the relationship between the degree of DR and renal function in T2DM patients was evaluated.Results The levels of urinary albumin/creatinine ratio (UACR),serum creatinine (SCr) and serum cystatin C (sCys-C) was (281.36 ±98.37)mg · g-1,(78.31 ± 16.08) μmol · L-1 and (1.17 ±0.32)mmol· L-1 in group DR,which were significantly higher than those in group NDR [(183.16 ±84.17)mg · g-1,(62.47 ± 15.21) μmol · L-1 and (0.83 ±0.21)mmol · L-1](all P ＜ 0.05),while the level of glomerular fitration rate (GFR) was (80.81 ± 23.21)mL · min-1 in DR group,which was lower than that of group NDR (89.83 ± 20.13)mL · min-1 (p ＜0.05).The levels of UACR,Scr and sCys-C increased gradually,while the level of GFR decreased gradually with the degree of DR progressing,and there were statistical differences in the levels of UACR,Scr,sCys-C and GFR in the four groups (all P ＜ 0.05).Furthermore,the differences in above variables in PDR group with mild NPDR and moderate NPDR were statistically significant (all P ＜ 0.05).Spearman rank correlation analysis showed that the degree of DR was positively correlated with UACR,Scr and sCys-C (all P ＜ 0.05),and negatively correlated with GFR (P ＜0.05).Conclusion The degree of DR in T2DM patients is closely related to the index of renal function,and elevated UACR,Scr and Cys-C and decreased GFR are the risk factors for DR.关键词
2型糖尿病/糖尿病视网膜病变/肾功能/相关性Key words
type 2 diabetes mellitus/diabetic retinopathy/renal function/correlation分类
医药卫生
