中国肺癌杂志2018，Vol.21Issue(5)：365-374,10.DOI:10.3779/j.issn.1009-3419.2018.05.03
循环肿瘤细胞中不同表型细胞FGFR1基因表达程度与非小细胞肺癌临床病理特点相关性研究
Relationship between FGFR1 Gene Regulation of Circulating Tumor Cells and Clinical Features of Non-small Cell Lung Cancer
摘要
Abstract
Background and objective The methods of detection for recurrence and metastasis in patients with non-small cell lung cancer (NSCLC) have hysteresis and one-sidedness. This study summarizes the relationship between the circulating tumor cell (CTC) in peripheral blood, expression of fibroblast growth factor receptor 1 (FGFR1) and clinic patho-logical features in 30 patients with NSCLC so as to provide new ideas for the detection of tumor recurrence and metastasis. Methods To analyze the clinical data and CTC detection data of 30 cases of NSCLC in Department of Thoracic Surgery, Peking Union Medical College Hospital from November 2016 to June 2017. Results Data analysis showed that the positive rate of CTC in peripheral blood was remarkably correlated with the smoking history (P=0.016). There was no significant cor-relation among the pathological type and CTC positive rate and the expression of FGFR1 (P=0.202, P=0.806). There was no significant difference in the expression of FGFR1 in different type CTC cells (P=0.094). Conclusion The positive rate of CTC was significantly correlated with the smoking history of patients with NSCLC. There was no significant difference in CTC classification and FGFR1 expression in different pathological types of NSCLC. There was no significant difference in the ex-pression of FGFR1 between different types of CTCs. We look forward to a larger sample size and inclusion of follow-up data to arrive at more clinically relevant conclusions about CTC and FGFR1 gene expression.关键词
肺肿瘤/循环肿瘤细胞/成纤维细胞生长因子受体1/吸烟史/转移Key words
Lung neoplasms/Circulating tumor cell/Fibroblast growth factor receptor 1/Smoking history/Metas-tasis引用本文复制引用
刘磊,黄诚,李力,梁乃新,李单青..循环肿瘤细胞中不同表型细胞FGFR1基因表达程度与非小细胞肺癌临床病理特点相关性研究[J].中国肺癌杂志,2018,21(5):365-374,10.基金项目
本研究受北京协和医学院青年教师项目(2014zlgc0717)、北京市自然科学基金面上项目(7182132)、 北京市科委重大课题(Z171100002017013)、北京市科委"首都特色"临床专项(Z151100004015157)、北京协和医院青年基金(PUMCH-2016-2.25,HI626500)和小规模特色办学项目(2014zlgc0135)资助This study was supported by the grants from PUMC Special Youth Teacher Project(2014zlgc0717),Beijing Natural Science Foundation(7182132),Major projects of the Beijing Municipal Science and Technology Commis-sion(Z171100002017013),Capital Special Project for Featured Clinical Application(Z151100004015157),The Peking Union Medical College Hospital Youth Fund(PUMCH-2016-2.25,HI626500)and PUMC Special Youth Teacher Project(2014zlgc0135)(all to Naixin LIANG). （2014zlgc0717）
