中国临床药理学杂志2018，Vol.34Issue(6)：626-628,635,4.DOI:10.13699/j.cnki.1001-6821.2018.06.005
谷氨酰胺联合益生菌治疗失代偿肝硬化患者的临床研究
Clinical trial of glutamine combined with probiotics in the treatment of patients with decompensated cirrhosis
摘要
Abstract
Objective To investigate the effect and safety of glutamine combined with probiotics on patients with decompensated cirrhosis.Methods Seventy-eight patients with decompensated cirrhosis were collected and randomly divided into two groups,the control group with 39 cases were treated with routine treatment,the treatment group with 39 cases were treated with compound glutamin entersoluble capsule 750 mg,tid,oral + live combined bacillus subtilis and enterococcus faecium enteric-coated capsules 250 mg,tid,oral on the basis of control group.The two groups were treated for 4 weeks.Before and after treatment,the permeability of the intestinal mucosa indexes,liver function indexes,the clinical effects and adverse drugs reactions (ADR) were measured and compared between two groups.Results After treatment,the ratio of lactulose/mannitol in urine of treatment group and control group were 0.09 ±0.06,0.12 ±0.08,and serum interleukin-8 in the two groups were(15.02 ± 3.69),(18.45 ± 4.10) ng· L-1,serum level of alanine aminotransferase in the two groups were (24.61 ± 14.29),(36.82 ± 15.67)U · L-1,the difference of above factors between the two groups was statistically significant (all P＜0.05).The improved rate in the control group 71.80％ was lower than the treatment group 92.31％ with significantly (P ＜0.05).The incidence rate of ADR in the control group was 15.38％ (6 cases/39cases),compared with 20.51％ (8 cases/39 cases) in the treatment group,there was no difference between the two groups (P ＜ 0.05).Conclusion Glutamine combined with probiotics is effective in the treatment of patients with decompensated cirrhosis,which is helpful to decrease the permeability of intestinal mucosa and improve the liver function;and doesn't increase ADR.关键词
谷氨酰胺/益生菌/失代偿肝硬化/乳果糖/甘露醇比值/白细胞介素-8Key words
glutamine/probiotics/decompensated cirrhosis/lactulose/mannitol ratio/interleukin-8分类
医药卫生引用本文复制引用
肖孟生,符丽珍,朱德康,韦玲..谷氨酰胺联合益生菌治疗失代偿肝硬化患者的临床研究[J].中国临床药理学杂志,2018,34(6):626-628,635,4.基金项目
海南省自然科学基金资助项目(309118) （309118）
