中国临床药理学杂志2018，Vol.34Issue(6)：632-635,4.DOI:10.13699/j.cnki.1001-6821.2018.06.007
血清高同型半胱氨酸在多发性骨髓瘤治疗及预后中的临床意义
Clinical significance of serum homocysteine levels in the treatment of multiple myeloma and prognosis
摘要
Abstract
Objective To analyze the clinical significance of serum homocysteine (Hcy) levels in the treatment and prognosis of multiple myeloma.Methods A total of 126 patients with multiple myeloma were included as treatment group,and 60 healthy subjects for physical examination in our hospital were included as control group.The differences of β2-microglobulin (β2-MG),hemoglobin (Hb),erythrocyte sedimentation rate (ESR),lactate dehydrogenase (LDH) and Hcy levels between treatment group and control group were analyzed.The treatment group were divided into Ⅰ,Ⅱ,Ⅲ stage groups according to pathological sta ges.The difference of β2-MG,Hb,ESR,LDH and Hcy levels in three groups was analyzed.The correlation between serum Hcy levels and β2-MG,Hb,ESR,LDH levels before treatment was analyzed by Pearson.The median survival of different Hcy levels in treatment group were analyzed.The effect of serum Hcy in the treatment and prognosis of patients with multiple myeloma was analyzed.Results The levels of serum β2-MG,ESR,LDH,Hcy and Hb in treatment group were (5.88±1.08)g · L-1,(79.84±9.67)mm· h-1,(323.59 ±23.57)U · L-1,(22.28 ± 3.76) μmol · L-1,(90.78 ± 10.15) g · L-1,had significant difference with those in control group,which were (2.87 ± 0.71) g · L-1,(18.92 ±3.64)mm · h-1,(156.82 ±19.83)U · L-1,(11.01 ±3.18) μmol · L-1,(141.62 ±15.27)g · L-1(all P ＜ 0.05).The levels of serum β2-MG,ESR,LDH,Hcy and Hb levels in stage Ⅱ and Ⅲ had significant difference with those in stage Ⅰ (P ＜ 0.05).The levels of serum β2-MG,ESR,LDH,Hcy and Hb in stage Ⅲ had significant difference with those in stage Ⅱ (P ＜ 0.05).Serum Hcy levels were positively correlated with the levels of β2-MG,ESR and LDH and negatively correlated with Hb (P ＜ 0.05).The median survival times in Hcy ≥ 22 μmol · L-1 and Hcy ＜ 22 μmol · L-1 groups were 31,38 months,with significant difference (P ＜ 0.05).Conclusion The serum levels of Hcy in patients with multiple myeloma were significantly higher,and the level of Hcy has a certain reference significance for the evaluation of therapeutic effect,and affects the prognosis of patients.关键词
多发性骨髓瘤/高同型半胱氨酸/临床疗效/预后Key words
multiple myeloma/homocysteine/therapeutic effect/prognosis分类
医药卫生引用本文复制引用
王赟,欧渤苒,刘慧娟,洪海波,安刚..血清高同型半胱氨酸在多发性骨髓瘤治疗及预后中的临床意义[J].中国临床药理学杂志,2018,34(6):632-635,4.基金项目
国家自然科学基金青年科学基金资助项目(81400175) （81400175）
