中国临床药理学杂志2018，Vol.34Issue(6)：636-639,4.DOI:10.13699/j.cnki.1001-6821.2018.06.008
儿茶酚-O-甲基转移酶基因Val158Met多态性与乳腺癌易感性关系研究
Association between catechol-O-methyl transferase Val158Met polymorphism and breast cancer susceptibility
摘要
Abstract
Objective To investigate whether single nucleotide polymorphisms of catechol-O-methyl transferase (COMT) of Val158Met are associated with the risk of breast cancer.Methods Gene polymorphisms of COMT were detected using di-allele-specific-amplification with artificially modified primers combined with SYBR Green I real-time polymerase chain reaction in a case-control study,which included 96 breast cancer patients (treatment group) and 116 healthy women(control group).Results The frequency of allele G in COMT gene Val158Met was 65.10％ and 71.98％ in treatment group and control group,and the frequency of allele A were 34.90％ and 28.02％ respectively.There were no differences between the two groups in allele frequencies of COMT Val158Met among Guangxi Baise population (all P ＞ 0.05).COMT Val158Met G/G genotype frequency distribution of the treatment group (38.54％) was lower than that of control group (54.31％),A/G genotype frequency distribution of the treatment group was higher(53.13％)than that of control group (35.34％).The distribution frequency differences of the two groups homozygous wild-type and heterozygous were statistically significant (all P ＜ 0.05).A/A genotype frequency distribution was relatively similar in the treatment group and control group,and they were 8.33％ and 10.35％ respectively.The breast cancer risks of Guangxi Baise women with A/G heterozygous genotype increased by 2.118 times compared with that of G/G homozygous genotype.Conclusion Gene polymorphism of COMT Val158Met may be associated with the risk of breast cancer.关键词
儿茶酚-O-甲基转移酶/Met158Val/基因多态性/乳腺癌/易感性Key words
catechol-O-methyl transferase/Val158Met/gene polymorphism/breast cancer/susceptibility分类
医药卫生引用本文复制引用
李曙波,廖长秀,罗莹,贺珊,李根亮,林瑶..儿茶酚-O-甲基转移酶基因Val158Met多态性与乳腺癌易感性关系研究[J].中国临床药理学杂志,2018,34(6):636-639,4.基金项目
广西省自然科学基金面上基金资助项目(2014GXNSFAA118214) （2014GXNSFAA118214）
