中国临床药理学杂志2018，Vol.34Issue(6)：653-655,3.DOI:10.13699/j.cnki.1001-6821.2018.06.013
丙泊酚注射剂剂量和诱导时间在维汉患者中的差异性研究
Differences of dosage and duration of anesthesia induced by propofol injection between Uygur and Han nationality
摘要
Abstract
Objective To observe the differences of dosage and duration of anesthesia induced by target controlled infusion with propofol between Uygur and Han nationality.Methods A total of 62 patients (in Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University) scheduled for general anesthesia surgery were divided into the Uygur ethnic group (n =31 cases) and the Han ethnic group (n =31 cases).Both groups received anesthesia induction through target controlled infusion with propofol (with target concentration of 3 μg · mL-1 in plasma).When Bispectral index (BIS) reduced to 50,both groups were given intravenous injection of 2 μg · kg-1 of fentanyl citrate and 0.15 mg · kg-1 of cis-atracurium.Tracheal intubation was performed after satisfactory relaxation.Heart rate (HR),systolic blood pressure (SBP),diastolic blood pressure (DBP),mean arterial pressure (MAP),propofol dosage,duration of anaesthesia induced by target controlled infusion with propofol from pre-induction (T0) to BIS at 50 (T1) and adverse drug reactions were compared between Uygur and Han nationality.Results After induction,no significant difference was found in HR,SBP,DBP and MAP between the Uygur and Han ethnic groups.There were significant differences between the two groups in the propofol dosage [(2.56 ± 0.39) mg · kg-1 vs (2.07 ± 0.30) mg · kg-1] and the duration of anesthesia (297.92 ± 47.10) s vs (229.27 ± 42.18) s] from T0 to T1 (P ＜0.01).No adverse drug reactions occurred in both groups.Conclusion The propofol dosage was remarkably higher and the duration of anesthesia was longer in the Uygur nationality than those in the Han nationality,and the difference should be noticed during clinical anesthesia.关键词
丙泊酚/靶控输注/全麻诱导/维吾尔族/汉族Key words
propofol/target controlled infusion/anesthesia induction/Uygur nationality/Han nationality分类
医药卫生引用本文复制引用
陈宝军,李淑萍,于婵娟,曹兴华..丙泊酚注射剂剂量和诱导时间在维汉患者中的差异性研究[J].中国临床药理学杂志,2018,34(6):653-655,3.基金项目
新疆维吾尔自治区自然科学基金青年基金资助项目(2014211C120) （2014211C120）
