中国临床药理学杂志2018，Vol.34Issue(6)：674-677,4.DOI:10.13699/j.cnki.1001-6821.2018.06.019
急诊科临床分离细菌耐药性分析
Analysis of bacterial resistance in clinical isolates of emergency department
李秀清 1秦冉冉 2高磊 3孙立颖 2熊辉 1汪波1
作者信息
- 1. 北京大学第一医院急诊科,北京100034
- 2. 北京大学第一医院检验科,北京100034
- 3. 北京大学第一医院临床药理研究所,北京100034
- 折叠
摘要
Abstract
Objective To investigate the distribution and antibiotic resistance of clinical isolates from patients in emergency department of Peking University First Hospital from 2012 to 2015.Methods Antimicrobial susceptibility testing was performed with Kirby-Bauer or automated instrument method.The results were analyzed by WHONET 5.6 software according to CLSI 2015 breakpoints.Results Of the 1283 clinical isolates,gram-positive bacteria and gram-negative bacteria accounted for 30.6％ and 69.4％ respectively.The 5 most common bacteria were Escherichia coli (18.4％),Acinetobacter baumannii (15.2％),Staphylococcus aureus(13.3％),Pseudomonas aeruginosa (12.7％),Klebsiella pneumoniae (8.8％).Methicillin-resistant Staphyloccus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococcus (MRCNS) accounted for 75.6％ and 83.1％.No Staphylococcal strain resistant to vancomycin,linezolid was detected.The resistance rate of E.faecalis strains to most of the antimicrobial agents tested was much lower than that of E.faecium.Extended-spectrum β-lactamase (ESBL)-producing strains accounted for 64.8％ and 40.5％ in E.coli and Klebsiellaspp respectively.The resistance rates of P.aeruginosa to imipenem and meropenem were 30.1％ and 28.4％.About 83.5％ and 83.0％ of A.baumannii were resistant to imipenem and meropenem.Conclusion The clinical isolated bacteria had high resistance to antibiotics.The detection rates of MRSA,vancomycin-resistant Enterococcus,extensively drug-resistant Enterobacteriaceae,extensively drug-resistant A.baumannii and extensively drug-resistant P.aeruginosa were high,which brought some challenges to clinical treatment.关键词
细菌耐药性监测/抗菌药物/泛耐药菌株Key words
bacterial resistance surveillance/antimicrobial susceptibility testing/extensively drug resistant bacteria分类
医药卫生引用本文复制引用
李秀清,秦冉冉,高磊,孙立颖,熊辉,汪波..急诊科临床分离细菌耐药性分析[J].中国临床药理学杂志,2018,34(6):674-677,4.
