中国临床药理学杂志2018，Vol.34Issue(7)：744-746,766,4.DOI:10.13699/j.cnki.1001-6821.2018.07.002
β七叶皂苷钠注射液联合布美他尼注射液治疗急性脑梗死伴脑水肿的临床研究
Clinical trial of β-aescin sodium injection combined with bumetanide injection in the treatment of acute cerebral infarction with cerebral edema
摘要
Abstract
Objective To observe the clinical efficacy and safety of β-aescin sodium injection combined with bumetanide injection in the treatment of acute cerebral infarction with cerebral edema.Methods Ninety -eight patients of acute cerebral infarction with cerebral edema were randomly divided into control and treatment groups with 49 cases per group.Control group was given 20％ mannitol injection 250 mL per time,qd,intravenous infusion.Treatment group was treated with β-aescin sodium injection 20 mg per time,qd,intravenous infusion + bumetanide injection 2 mg per time,qd,intravenous injection,on the basis of control group.Two groups were treated for 7-10 days.The clinical efficacy,superoxide dismutase (SOD),interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α) and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 85.71％ (42 cases/49 cases) and 67.35 ％ (33 cases/49 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:SOD were (64.71 ± 8.19) and (59.65 ± 8.52) kU · L-1,IL-6 were (54.03±7.53) and (65.49±6.93)ng· L-1,TNF-α were (8.59:±0.89) and (9.54 ±l.00)ng· L-1,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions in treatment group were hyperglycemia,electrolyte disorder and urinalysis abnormality,which in control group were electrolyte disorder and urinalysis abnormality.The total incidences of adverse drug reactions in treatment and control groups were 14.29％ and 12.24％ without significant difference (P ＞0.05).Conclusion β-aescin sodium injection combined with bumetanide injection has a definitive clinical efficacy in the treatment of acute cerebral infarction with cerebral edema,which can effectively improve the level of oxidative stress and inflammatory factors,without increasing the incidence of adverse drug reactions.关键词
β七叶皂苷钠注射液/布美他尼注射液/急性脑梗死/脑水肿/安全性Key words
β-aescinate injection/bumetanide injection/acute cerebral infarction/cerebral edema/safety分类
医药卫生引用本文复制引用
文雯,陈艳,凌天金,郭海志,张天林,余能伟..β七叶皂苷钠注射液联合布美他尼注射液治疗急性脑梗死伴脑水肿的临床研究[J].中国临床药理学杂志,2018,34(7):744-746,766,4.基金项目
四川省卫生厅科研基金资助项目(110231) （110231）
