中国临床药理学杂志2018，Vol.34Issue(7)：747-749,3.DOI:10.13699/j.cnki.1001-6821.2018.07.003
纳洛酮注射液联合布美他尼注射液治疗急性脑梗死后脑水肿的临床研究
Clinical trial of naloxone injection combined with bumetanide injection in the treatment of cerebral edema after acute cerebral infarction
摘要
Abstract
Objective To observe the clinical efficacy and safety of naloxone injection combined with bumetanide injection in the treatment of cerebral edema after acute cerebral infarction.Methods Eighty-two patients with cerebral edema after acute cerebral infarction were randomly divided into control and treatment groups with 41 cases per group.Control group was treated with 20％ mannitol injection100 mL per time,qd,intravenous drip,continuous use for 7-10 days.Treatment group was treated with naloxone 4 mg per time,qd,intravenous drip,continuous use for 14 d + bumetanil 2 mg per time,qd,intravenous injection,continuous use for 7-10 days,on the basis of control group.The clinical efficacy,S-100β,neuronal specific enolase (NSE),myelin basic protein (MBP),cerebral edema volume and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 95.12％ (39 cases/41 cases) and 75.61％ (31 cases/41 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:S-100β were(0.42 ± 0.05) and (0.54 ± 0.07) μg · L-1,NSE were (9.48 ± 1.29) and (12.73 ± 1.62)μg · L-1,MBP were (1.43 ± 0.17) and (1.72 ± 0.28)μg · L-1,cerebral edema volume were (20.31 ± 2.52) and (24.53 ± 3.15) mL,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions of two groups were electrolyte disorders and urinalysis.The total incidences of adverse drug reactions in treatment and control groups were 12.20％ and 17.07％ without significant difference (P ＞ 0.05).Conclusion Naloxone injection combined with bumetanide injection has a definitive clinical efficacy in the treatment of cerebral edema after acute cerebral infarction,which can significantly reduce the Levels of S-100β,NSE and MBP,without increasing the incidence of adverse drug reactions.关键词
纳洛酮注射液/布美他尼注射液/急性脑梗死/脑水肿/安全性Key words
naloxone injection/bumetanide injection/acute cerebral infarction/brain edema/safety分类
医药卫生引用本文复制引用
张立华,张铁麟,张敬国..纳洛酮注射液联合布美他尼注射液治疗急性脑梗死后脑水肿的临床研究[J].中国临床药理学杂志,2018,34(7):747-749,3.基金项目
河北省医学科学研究重点课题计划基金资助项目(ZL20140279) （ZL20140279）
