中国临床药理学杂志2018，Vol.34Issue(7)：753-755,3.DOI:10.13699/j.cnki.1001-6821.2018.07.005
依达拉奉注射液联合阿司匹林肠溶片治疗急性缺血性脑卒中的临床研究
Clinical trial of edaravone injection combined with aspirin enteric-coated tablets in the treatment of acute ischemic stroke
摘要
Abstract
Objective To observe the clinical efficacy and safety of edaravone injection combined with aspirin enteric-coated tablets in the treatment of acute ischemic stroke.Methods A total of 114 patients with acute ischemic stroke were divided into control group and treatment group with 57 cases per group.Control group was given aspirin 100 mg per time,qd,orally.Treatment group was given edaravone 30 mg per time,bid,intravenous drip within 30 min,on the basis of control group.Two groups were treated for 2 weeks.The clinical efficacy,national institutes of health stroke scale (NIHSS) scores,serum lipoprotein-associated phospholipase A2 (Lp-PLA2),arachidonic acid (AA) and adenosine diphosphate (ADP) induced inhibition rates of platelet aggregation,and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 91.23％ (52 cases / 57 cases) and 68.42％ (39 cases / 57 cases) with significant difference (P ＜0.05).After treatment,the main indexes in treatment and control groups were compared:the NIHSS scores were (5.53 ± 1.24) and (10.02 ± 1.26) points,Lp-PLA2 were (18.00 ±4.68) and (31.84 ±5.62) μg · L-1,The inhibition rates of platelet aggregation induced by AA were (94.50 ±3.16)％ and (70.65 ±3.60)％,which induced by ADP were (56.49 ±0.36)％ and (45.21 ±0.87)％,the differences were statistically significant (all P ＜0.05).The adverse drug reactions in treatment group were headache,which in control group were drug allergies,headaches and tinnitus.The total incidences of adverse drug reactions in treatment and control groups were 1.75％ and 10.53％ without significant difference (P ＞ 0.05).Conclusion Edaravone injection combined with aspirin enteric-coated tablets has a definitive clinical efficacy in the treatment of acute ischemic stroke,which can significantly reduce the levels of Lp-PLA2,improve the AA and ADP induced inhibition rates of platelet aggregation,without increasing the incidence of adverse drug reactions.关键词
依达拉奉注射液/阿司匹林肠溶片/急性缺血性脑卒中/安全性Key words
edaravone injection/aspirin enteric-coated tablet/acute ischemic stroke/safety分类
医药卫生引用本文复制引用
刘晓霞,朱蓓蕾,杨迎民..依达拉奉注射液联合阿司匹林肠溶片治疗急性缺血性脑卒中的临床研究[J].中国临床药理学杂志,2018,34(7):753-755,3.基金项目
浙江省医药卫生计划基金资助项目(2011ZHA011,2011KYB057) （2011ZHA011,2011KYB057）
