摘要
Abstract
Objective To study the clinical efficacy and safety profile of high doses of rosuvastatin tablets in the treatment of acute myocardial infarction.Methods A total of 126 patients with acute myocardial infarction were randomly divided into the control group (n =63) and the treatment group (n =63).The control group received oral administration of 10 mg resuvastatin once daily at night time.The treatment group was given oral administration of 20 mg resuvastatin once daily at night time.Both groups were treated for 1 month.The clinical efficacy,serum cardiac troponin T(cTnT),homocysteine (Hcy),cystatin C (Cys-C),soluble CD40 ligand (sCD40L) level,and adverse drug reactions were compared between the two groups.Results After treatment,the total effective rate of the treatment group and control group were 95.24％ (60 cases/63 cases) and 84.13％ (53 cases/63 cases),respectively,and the difference was statistically significant (P ＜ 0.05).After treatment,there were significant differences between the treatment group and the control group in the level of cTnT [(2.14 ± 0.38) μg · L-1 vs (4.83±0.75) μg · L-1],Hcy [(13.21 ±2.07) μmol · L-1 vs (16.32±2.64) μmol · L-1],Cys-C [(0.58±0.08) mg · L-1 vs (1.11 ±0.17) mg· L-1] and sCD40L [(3.06 + 0.57) μg· L-1 vs (4.26 ±0.71) μg· L-1](allP＜0.05).The adverse drug reaction in the treatment group was recurrent myocardial infarction,and the adverse drug reactions in the control group were recurrent myocardial infarction and revascularization.The incidences of adverse drug reactions in treatment group and the control group were 3.17％ and 6.35％,respectively,with no significant difference (P ＞ 0.05).Conclusion Rosuvastatin,especially high-dose rosuvastatin,exerted high clinical efficacy in patients with acute myocardial infarction via improving heart function and reducing the level of serum cTnT,Hcy,Cys-C and sCD40L,while providing good safety profile.关键词
瑞舒伐他汀片/盐酸替罗非班注射液/急性心肌梗死/安全性Key words
rishuvastatin tablet/tirofiban hydrochloride injection/acute myocardial infarction/safety分类
医药卫生
