中国临床药理学杂志2018，Vol.34Issue(7)：760-762,3.DOI:10.13699/j.cnki.1001-6821.2018.07.007
丹参川芎嗪注射液联合阿托伐他汀钙片治疗老年高血压的临床研究
Clinical trial of salviae miltiorrhizae and ligustrazine hydrochloride injection combined with atorvastatin calcium tablets in the treatment of senile hypertension
摘要
Abstract
Objective To observe the clinical efficacy and safety of salviae miltiorrhizae and ligustrazine hydrochloride injection combined with atorvastatin calcium tablets in the treatment of senile hypertension.Methods Ninety-six elderly patients with hypertension were randomly divided into control and treatment groups with 48 cases per group.Control group was treated with atorvastatin calcium 20 mg per time,qd,orally.Treatment group was given salviae mihiorrhizae and ligustrazine hydrochloride injection 10 mL per time,qd,intravenous drip,on the basis of control group.Two groups were treated for 2 weeks.Then clinical efficacy and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 85.42％ (41 cases / 48 cases) and 66.67％ (32 cases /48 cases) with significant difference (P ＜ 0.05).The adverse drug reactions of treatment group were dizziness and gastrointestinal discomfort,which in control group were gastrointestinal discomfort and elevated alanine transaminase.The incidences of adverse drug reactions in treatment and control groups were 6.25％ and 8.33％ without significant difference (P ＞0.05).Conclusion Salviae miltiorrhizae and ligustrazine hydrochloride injection combined with atorvastatin calcium tablets has a definitve clinical efficacy and safety in treatment of senile hypertension.关键词
丹参川芎嗪注射液/阿托伐他汀钙片/老年高血压/安全性Key words
salviae miltiorrhizae and ligustrazine hydrochloride injection/atorvastatin calcium tablet/senile hypertension/safety分类
医药卫生引用本文复制引用
王玉珍,王诗尧,王秀艳..丹参川芎嗪注射液联合阿托伐他汀钙片治疗老年高血压的临床研究[J].中国临床药理学杂志,2018,34(7):760-762,3.基金项目
河北省医学科学研究重点课题计划基金资助项目(20160755) （20160755）
