中国临床药理学杂志2018，Vol.34Issue(7)：774-776,3.DOI:10.13699/j.cnki.1001-6821.2018.07.011
多柔吡星注射剂治疗带状疱疹后遗神经痛的临床研究
Clinical trial of doxorubicin injection in the treatment of post-herpetic neuralgia
摘要
Abstract
Objective To observe the clinical efficacy and safety of doxorubicin injection in the treatment of post-herpetic neuralgia.Methods One hundred and four patients with post-herpetic neuralgia were randomly divided into control and treatment groups with 52 cases per group.Control group was given pulse radiofrequency therapy with 3 min per time,twice a week.Treatment group was given doxorubicin 10 mg per time,once two weeks,intervertebral foramen injection.Two groups were treated for 4 weeks.The clinical efficacy,visual analogue scale (VAS) scores,the levels of serum interleukin-6 (IL-6) and IL-10,and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 86.54％ (45 cases/52 cases) and 69.23％ (36 cases/52 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:IL-6 were (174.83±23.72) and (321.65 ±45.82) pg · mL-1,IL-10 were (183.46 ±28.11) and (164.67 ±21.31) μg · mL-1,VAS were (2.32 ±0.65) and (3.51 ±0.84) score,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions in treatment group were skin numbness in block area and palpitation,and no adverse drug reactions occurred in control group.The incidences of adverse drug reactions in treatment and control groups were 5.77％ and 0 without significant difference (P ＞ 0.05).Conclusion Doxorubicin injection has a definitive clinical efficacy in the treatment of post-herpetic neuralgia,which can significantly balance the inflammatory factors,improve the pain,without increasing the incidence of adverse drug reactions.关键词
多柔吡星注射剂/带状疱疹后遗神经痛/安全性Key words
doxorubicin injection/post-herpetic neuralgia/safety分类
医药卫生引用本文复制引用
王一雄,许宝珠,颜景佳,江长城,庄渊钊,周建英..多柔吡星注射剂治疗带状疱疹后遗神经痛的临床研究[J].中国临床药理学杂志,2018,34(7):774-776,3.基金项目
泉州市科技局技术研究与开发基金资助项目(20132157) （20132157）
