中国临床药理学杂志2018，Vol.34Issue(7)：783-785,792,4.DOI:10.13699/j.cnki.1001-6821.2018.07.014
2型糖尿病对脑梗死患者血小板衍生内皮细胞生长因子和血管内皮细胞生长因子的影响
Effect of type 2 diabetes mellitus on the platelet derived endothelial cell growth factor and vascular endothelial growth factor in patients with cerebral infarction
摘要
Abstract
Objective To observe the effect of type 2 diabetes mellitus on serum platelet-derived endothelial cell growth factor (PD-ECGF) and vascular endothelial growth factor (YEGF) in patients with acute cerebral infarction.Methods Seventy-three patients with acute cerebral infarction (32 patients with non-concomitant diabetes were assigned to group A,and 41 patients with diabetes were assigned to group B),30 cases of type 2 diabetes mellitus patients with non-cerebrovascular disease hospitalized in the same period (group C),and 30 patients without cerebrovascular disease and diabetes mellitus (group D) were the subjects.The serum levels of PD-ECGF and VEGF in group A and group B were measured at 1,3,7,10 to 14 days after onset by double antibody sandwich enzyme-linked immunosorbent assay,which in group C and group D were measured at 1 st day..NIHSS scores were performed on group A and group B using the NIHSS Score (NIHSS) scale.Results The levels of PD-ECGF in group A were (5.93 ± 1.25),(5.93 ± 1.25),(4.19 ± 1.23),(3.67 ± 1.06) μg · mL-1,at 1,3,7,10 to 14 days after onset,The levels of PD-ECGF in group B were (2.88 ±0.54),(2.84 ±0.53),(2.81 ±0.41) and (2.86 ± 0.49) μg · mL-1.The VEGF levels in group A were (172.32 ± 31.91),(158.91 ± 31.84),(158.69 ± 29.27),(156.92±38.16),(159.64 ±27.21) and (159.91 ±40.25) pg· mL-1,The levels of VEGF in group B were (154.91 ±31.84),(158.69 ±29.27),(156.92 ±38.16),(159.64 ±27.21) pg · mL-1,the differences were statistically significant (all P ＜ 0.05).On the first day of admission,the PD-ECGF of group C and D were (2.25±0.49),(2.79±0.51) μg·mL-1,the VEGF were (94.90±19.85),(151.11±130.33) pg· mL-1,the differences were statistically significant (all P ＜ 0.05).The scores of NIHSS in group A and group B were (12.52 ±3.25) and (12.89 ±2.56).The difference was not statistically significant (P ＞ 0.05).On the 10 th to 14th day after onset,the NIHSS scores of group A and group B were (6.48 ± 2.15) and (4.24 ± 1.87) respectively,the difference was statistically significant (P ＜ 0.05).Conclusion Type 2 diabetes can reduce the expression of PD-ECGF and VEGF in patients with cerebral infarction and affect the prognosis of patients with type 2 diabetes mellitus.关键词
脑梗死/2型糖尿病/血小板衍生内皮细胞生长因子/血管内皮细胞生长因子Key words
cerebral infarction/type 2 diabetes mellitus/platelet derived endothelial cell growth factor/vascular endothelial growth factor分类
医药卫生引用本文复制引用
钱淑霞,沈宇斐,张晓玲,官俏兵..2型糖尿病对脑梗死患者血小板衍生内皮细胞生长因子和血管内皮细胞生长因子的影响[J].中国临床药理学杂志,2018,34(7):783-785,792,4.基金项目
浙江省中医药科学研究基金资助项目(2010ZB147) （2010ZB147）
嘉兴市科技局计划基金资助项目(2015AY23021) （2015AY23021）
