中国临床药理学杂志2018，Vol.34Issue(7)：812-814,3.DOI:10.13699/j.cnki.1001-6821.2018.07.023
紧密连接蛋白在人宫颈癌组织中的表达及其临床意义
Expression of Occludin protein in cervical cancer and its clinical significance
摘要
Abstract
Objective To analyze the expression of Occludin in human cervical cancer and its clinical significance.Methods Forty patients with cervical cancer were selected as the research object,and the expression of Occludin in 40 couples of cancer tissue and normal tissue were measured by Western Blotting.The correlation between expression of Occludin protein and clinical characteristics was analyzed.Results In the cancer and normal tissues,the low expression rates of Occludin protein were 62.50％ (25 cases / 40 cases) and 77.50％ (31 cases /40 cases),the high expression rates of Occludin protein were 37.50％ (15 cases / 40 cases) and 22.50％ (9 cases/40 cases),the expression quantity of Occludin protein were (0.39 ± 0.34) and (0.11 ± 0.11),the differences were statistically significant(all P ＜0.05).There was no significant correlation between the level of Occludin expression and patients' age,tumor size,FIGO stage,pathological grading and lymph node metastasis (all P ＞ 0.05).Conclusion Down-regulation of Occludin protein was observed in cervical cancer tissues,which may contribute to the development of cervical cancer.However,it was not correlated with the patients' clinical characteristics.关键词
紧密连接蛋白/宫颈癌/临床病理特征Key words
Occludin/cervical cancer/clinical characteristics分类
医药卫生引用本文复制引用
张彬,陈丽红,邹亦庐,包秋芳..紧密连接蛋白在人宫颈癌组织中的表达及其临床意义[J].中国临床药理学杂志,2018,34(7):812-814,3.基金项目
福建省自然科学基金资助项目(2017J01282) （2017J01282）
