中国美容医学2018，Vol.27Issue(4)：136-140,5.
细胞自噬与衰老的相关性研究进展
Advances in the Correlation between Autophagy and Aging
摘要
Abstract
Aging is one of the necessary stage for every organism from birth to death,and autophagy is one of the most popular fieldss of current life science research following apoptosis. We analyzed the effects of autophagy on the aging process from enhancement and attenuation of the cell autophagy function, reviewed related studies on the correlation between aging and autophagy, and analyzed the role of mTOR, AMPK signaling pathway and p53 protein at the molecular level on aging-autophagy, the important regulatory mechanism by which cells adapt to internal and external environment. Thus suggested that autophagy can regulate cell aging process. Therefore, the use of cell autophagy to treat some aging diseases (such as cancer, cardiovascular disease, neurodegenerative diseases, etc.) will surely be the focus of future medical research.关键词
衰老/细胞自噬/mTOR-AMPK信号通路/p53/研究进展Key words
aging/autophagy/mTOR-AMPK signaling pathway/p53 protein/review分类
医药卫生引用本文复制引用
史敏,陈雷,尚丛珊..细胞自噬与衰老的相关性研究进展[J].中国美容医学,2018,27(4):136-140,5.基金项目
1.2017年陕西省教育厅项目"泾渭茯茶中TPS的提取及对ALX模型小鼠降糖作用机制的研究"(编号:17JK1057) （编号:17JK1057）
2.2017年西安培华校级科研项目"细胞自噬在糖尿病大鼠心肌缺血/再灌注损伤的变化及机制研究"(编号:2017phky061) （编号:2017phky061）
