中国现代医学杂志2018，Vol.28Issue(14)：31-34,4.DOI:10.3969/j.issn.1005-8982.2018.014.006
美伐他汀降低β-淀粉样蛋白神经毒性的体外研究
Study on mechanism of Mevastatin protection from neurotoxicity induced by amyliod-β
黄美媚 1黎宏庄 1欧阳基鹏 1李国兴 1黎泳欣 1甘育鸿2
作者信息
- 1. 南方医科大学附属顺德第一人民医院 神经内科,广东 佛山 528300
- 2. 广东医学院天然药物研究与开发重点实验室,广东 湛江 524023
- 折叠
摘要
Abstract
Objective To explore the possibility of Mevastatin treatment for Alzheimer's disease from the perspective of the mechanism of reducing amyloid-β (Aβ) neurotoxicity in vitro. Methods Neural cells were cultured in the laboratory and Mevastatin was added to observe whether Mevastatin could activate adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), and the hyperphosphorylation induced by Aβ could be suppressed. Results Aβ reduced the number of SK-N-MC, the situation was improved after adding Mevastatin. Western blot revealed phosphorylation of AMPK in the SK-N-MC after exposure to Mevastatin for 24 h. Conclusions We hypothesized that Mevastatin may be against the toxicity of beta-amyloid protein through enhancing the activity of AMPK, and further inhibit the phosphorylation of Tau to achieve its neuroprotective effect.关键词
美伐他汀/阿尔茨海默病/β-淀粉样蛋白Key words
Mevastatin/Alzheimer's disease/β-amyloid peptide分类
医药卫生引用本文复制引用
黄美媚,黎宏庄,欧阳基鹏,李国兴,黎泳欣,甘育鸿..美伐他汀降低β-淀粉样蛋白神经毒性的体外研究[J].中国现代医学杂志,2018,28(14):31-34,4.
