中国现代医学杂志2018，Vol.28Issue(14)：40-45,6.DOI:10.3969/j.issn.1005-8982.2018.014.008
氨基酸转运蛋白家族成员在膀胱癌中的表达及其临床意义
Expressions of amino acid transporters in bladder cancer tissues and their clinical significance
曾繁畅 1唐正严 1岑松 2康新立2
作者信息
- 1. 中南大学湘雅医院 泌尿外科,湖南 长沙 410008
- 2. 海南省人民医院 泌尿外科,海南 海口 570311
- 折叠
摘要
Abstract
Objective To investigate the clinicopathological significance of the amino acid transporters in patients with bladder cancer. Methods The surgically resected bladder cancer tissues of 93 patients were stained by immunohistochemistry for detection of the expressions of L-type amino acid transporter 1 (LAT1), system ASC amino acid transporter 2 (ASCT2), x-C-type cystine/glutamate transporter (xCT), Ki-67 and CD34. Results The positive expresseion rates of LAT1, ASCT2 and xCT were 55.9% (52/93), 77.4% (72/93) and 65.6% (61/93), respectively. Positive ASCT2 expression was significantly associated with LAT1 and Ki-67 expressions. By univariate analysis, ASCT2 expression and disease stage had close relationships with overall survival. Tumor size and disease stage had close relationships with disease-free survival. Multivariate analysis confirmed that ASCT2 expression was an independent predictor for poor outcome after surgery. Conclusions ASCT2 can serve as a significant marker for prediction of negative prognosis after surgery.关键词
氨基酸转运蛋白家族/膀胱癌/预后Key words
amino acid transporter/bladder cancer/prognosis分类
医药卫生引用本文复制引用
曾繁畅,唐正严,岑松,康新立..氨基酸转运蛋白家族成员在膀胱癌中的表达及其临床意义[J].中国现代医学杂志,2018,28(14):40-45,6.
