中国现代医学杂志2018，Vol.28Issue(14)：71-75,5.DOI:10.3969/j.issn.1005-8982.2018.014.014
脑白质疏松症患者情感淡漠与同型半胱氨酸水平的关系
Relationships among leukoaraiosis, apathy and homocysteine
刘玉洁 1高春岭 1徐磊 1王竞达 1谭华1
作者信息
- 1. 西南医科大学附属医院 神经内科,四川 泸州 646000
- 折叠
摘要
Abstract
Objective To investigate the prevalence of apathy in patients with leukoaraiosis (LA), moreover, to analyze the possible relationships between those two and the plasma level of total homocysteine (tHcy). Methods Fourty-four patients with LA confirmed by magnetic resonance imaging and the same number of healthy controls were recruited from the Affiliated Hospital of Southwest Medical University. The Modified Apathy Evaluation Scale was used to identify whether there was apathy in the participants (score >14). Fasting venous blood was collected to assess the total plasma homocysteine level. At last, the possible relationships among leukoaraiosis, apathy and homocysteine were examined. Results The patients with leukoaraiosis had a higher prevalence of apathy than the healthy controls (P < 0.05). In addition, the tHcy level in the patients with LA was significantly higher than that in the control group (P < 0.05). Moreover, moderate or severe leukoaraiosis patients had obviously higher homocysteine levels than the patients with only mild leukoaraiosis (P < 0.05). In the participants with leukoaraiosis, the apathetic patients also had a significantly higher homocysteine level than those without apathy (P < 0.05). Conclusions First, leukoaraiosis patients are more likely to suffer from apathy compared to healthy people. Second, the total plasma homocysteine level is associated with the presence of leukoaraiosis, besides, it is related to the severity of white matter lesions. At last, there is an significantly higher homocysteine level in leukoaraiosis patients with apathy than those without apathy. Homocysteine may play a role in the presence of both leukoaraiosis and apathy.关键词
脑白质疏松症/同型半胱氨酸/情感淡漠Key words
leukoaraiosis/apathy/homocysteine分类
医药卫生引用本文复制引用
刘玉洁,高春岭,徐磊,王竞达,谭华..脑白质疏松症患者情感淡漠与同型半胱氨酸水平的关系[J].中国现代医学杂志,2018,28(14):71-75,5.
