中国现代医学杂志2018，Vol.28Issue(14)：76-79,4.DOI:10.3969/j.issn.1005-8982.2018.014.015
血清趋化素水平与慢性心力衰竭患者左室重构的相关性研究
Association between serum chemerin expression and left ventricular remodeling in patients with chronic heart failure
王蒙琴 1金树琦 1张柱 1马俊彪 1宋俊挺 1马莉1
作者信息
- 1. 包头医学院第一附属医院,内蒙古 包头 014010
- 折叠
摘要
Abstract
Objective To determine the level of serum chemerin and investigate the correlation between chemerin and ventricular remodeling in patients with chronic heart failure (CHF). Methods Sixty patients with chronic heart failure were selected as CHF group in this study (16 cases with cardiac function grade II, 26 cases with grade III, and 18 cases with grade IV). Menwhile 60 patients with normal cardiac function were enrolled as control group. Ultrasound echocardiography was performed to measure left ventricular ejection fraction (LVEF), left atrial diameter (LAD), left ventricular end diastolic diameter (LVEDD), interventricular septal thickness (IVST) and left ventricular posterior wall thickness (LVPWT), and then left ventricular mass (LVM) and left ventricular mass index (LVMI) were calculated. The serum level of chemerin was measured in all the selected subjects. Results The serum level of chemerin in the patients of the CHF group was significantly higher than that in the control group and increased with the exacerbation of heart failure (P < 0.05). And the serum chemerin level was positively correlated with LVMI (r = 0.401, P = 0.022), but was negatively correlated with LVEF (r = -0.455, P=0.021). Conclusions Serum chemerin is related to the left ventricular remodeling and can be identified as a new marker for heart failure. It may be used to assess the extent of heart failure and evaluate the prognosis of heart failure.关键词
血清趋化素/心力衰竭/心室重构/心脏功能Key words
chemerin/serum/heart failure/left ventricular remodeling/cardiac function分类
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王蒙琴,金树琦,张柱,马俊彪,宋俊挺,马莉..血清趋化素水平与慢性心力衰竭患者左室重构的相关性研究[J].中国现代医学杂志,2018,28(14):76-79,4.
