中国现代医学杂志2018，Vol.28Issue(14)：80-83,4.DOI:10.3969/j.issn.1005-8982.2018.014.016
幽门螺旋杆菌根除治疗现状及影响因素分析
Current rate of Helicobacter pylori eradication and its influencing factors: a retrospective study
王江源 1刘玉兰1
作者信息
- 1. 北京大学人民医院 消化内科,北京 100044
- 折叠
摘要
Abstract
Objective To investigate the current eradication rate of Helicobacter pylori and its influencing factors in Peking University People's Hospital. Methods A retrospective study was performed on 3,998 Helicobacter pylori-positive patients admitted to our hospital for initial eradication treatment between January 2014 and December 2015. All the patients were given quadruple therapy containing bismuth for a course of 7-14 d. The eradication effect was evaluated by 13C-urea Breath Test within 4-12 weeks after treatment. Results All of 3,998 patients received standard 7-14 day quadruple therapy: proton pump inhibitor (PPI)+2 antibiotics+bismuth. In total, the eradication rate was 74.9%. The eradication rates of regimens containing Amoxicillin plus Clindamycin, Amoxicillin plus Levofloxacin and Amoxicillin plus Metronidazole/Tinidazole were 77.8%, 80.6% and 71.8%, respectively (P > 0.05). The eradication rates of regimens containing Clindamycin plus Levofloxacin, Clindamycin plus Metronidazole/Tinidazole and Levofloxacin plus Metronidazole/Tinidazole were 70.5%, 55.7% and 74.7%, respectively (P > 0.05). Amoxicillin-containing regimens had a higher total eradication rate than the regimens without Amoxicillin (77.6% vs 69.8%, P < 0.05). Multivariate logistic regression analysis showed that the duration of therapy and the choice of antibiotics were independent predictors of treatment failure. Conclusions The current quadruple therapy has a very high failure rate in Beijing, China. Amoxicillin-containing regimens and longer treatment duration may increase the eradication rate.关键词
幽门螺旋杆菌/四联疗法/根除率Key words
Helicobacter pylori/quadruple therapy/eradication rate分类
医药卫生引用本文复制引用
王江源,刘玉兰..幽门螺旋杆菌根除治疗现状及影响因素分析[J].中国现代医学杂志,2018,28(14):80-83,4.
