中国医学科学院学报2018，Vol.40Issue(2)：146-150,5.DOI:10.3881/j.issn.1000-503X.2018.02.002
瘤周水肿区最小表观扩散系数值在原发中枢神经系统淋巴瘤与胶质母细胞瘤中的鉴别诊断价值
Value of Minimum Apparent Diffusion Coefficient in Peritumoral Edema in the Differential Diagnosis between Primary Central Nervous System Lymphoma and Glioblastoma
摘要
Abstract
Objective To evaluate the role of minimum apparent diffusion coefficient (MinADC) values in peritumoral edema based on magnetic resonance diffusion weighted imaging in the differential diagnosis between primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM).Methods ADC values in peritumoral edema were measured in 16 patients with PCNSL (diffuse large B cell lymphoma) and 31 patients with GBM (WHO grade Ⅳ) confirmed by pathology.Regions of interests were manually drawn on ADC maps on peritumoral edema regions to obtain the MinADC value.Independent samples t-test and receiver operating characteristic analysis were performed for statistical analysis.Results The MinADC value [(1.20-1.45) × 10-3 mm2/s,mean (1.35 ±0.68) × 10-3 mm2/s] in PCNSL was significantly higher than that in GBM [(0.95-1.31) × 10-3 mm2/s,mean (1.12 ±0.09) ×10-3 mm2/s] (t =9.977,P =0.000).The area under the receiver operating characteristic curve was 0.986,and the cutoff value of MinADC was 1.245 × 10-3 mm2/s for the differentiation between PCNSL and GBM,with the best combination of sensitivity (94.1％) and specificity (94.1％).Conclusion MinADC value can be a simple and effective measure for the differential diagnosis between PCNSL and GBM.关键词
淋巴瘤/胶质母细胞瘤/表观扩散系数/瘤周水肿区Key words
lymphoma/glioblastoma/apparent diffusion coefficient/peritumoral edema region分类
医药卫生引用本文复制引用
李鸣歌,陈志晔,刘刚,肖华锋,陈新静,娄昕,马林..瘤周水肿区最小表观扩散系数值在原发中枢神经系统淋巴瘤与胶质母细胞瘤中的鉴别诊断价值[J].中国医学科学院学报,2018,40(2):146-150,5.基金项目
中国人民解放军总医院百项优势基金(YS201457)Supported by Chinese PLA General Hospital Hundred Advantages Foundation (YS201457) （YS201457）
