中国医学科学院学报2018，Vol.40Issue(2)：158-162,5.DOI:10.3881/j.issn.1000-503X.2018.02.004
药物过量使用性头痛患者脑干结构变化初步磁共振成像评估
Altered Brainstem Volume in Medication-overuse Headache:A Pilot Magnetic Resonance Imaging Evaluation
摘要
Abstract
Objective To investigate the altered brainstem volume in patients with medication-overuse headache (MOH).Methods The high-resolution structural images were obtained from 36 MOH patients and 32 normal controls (NC).The brainstem was segmented into midbrain,pons,and medulla,whose volume were measured respectively.Results There was a significantly smaller midbrain volume in MOH patients [(5.80 ±0.53) ml] than that in NC [(6.14 ±0.67) ml] (t =2.36,P =0.02).The volumes of pons,medulla,and whole brainstem showed no significant difference in MOH patients [(13.13 ± 1.42) ml,(4.55 ± 0.51) ml,and (23.48 ±2.23) ml,respectively] compared with those in NC [(13.67 ± 1.61) ml,(4.66±0.44) rnl,and (24.47±2.56) ml,respectively] (tpons =1.47,Ppons =0.15;tmedulla =0.93,Pmedulla =0.35;and tbrainstem =1.71,Pbrainstem =0.09,respectively).Conclusion A smaller midbrain volume may be one of the specific features of pain pathway in MOH,and the automated brainstem subfield segmentation and volumetry may be useful tools for evaluating brainstem alternation in MOH patients.关键词
药物过量使用性头痛/中脑/脑桥/延髓/脑干Key words
medication-overuse headache/midbrain/pons/medulla/brainstem分类
医药卫生引用本文复制引用
陈志晔,陈小燕,刘梦琦,马林,于生元..药物过量使用性头痛患者脑干结构变化初步磁共振成像评估[J].中国医学科学院学报,2018,40(2):158-162,5.基金项目
海南省自然科学基金(818MS153)Supported by Hainan Provincial Natural Sciences Foundation of China (818MS153) （818MS153）
