中国医学科学院学报2018，Vol.40Issue(2)：211-218,8.DOI:10.3881/j.issn.1000-503X.2018.02.011
恶性腹膜间皮瘤25例临床分析
Clinical Analysis of 25 Cases of Malignant Peritoneal Mesothelioma
李宁宁 1白春梅 1王颖轶 1葛郁平 1赵林1
作者信息
- 1. 中国医学科学院 北京协和医学院 北京协和医院肿瘤内科,北京100032
- 折叠
摘要
Abstract
Objective To investigate the clinicopathological features,treatment,and prognosis of patients with malignant peritoneal mesothelioma (MPM).Method Clinical data of 25 MPM patients admitted to Peking Union Medical College Hospital from 1993 to 2017 were retrospectively analyzed.Results The mean age of these 25 patients with pathologically confirmed MPM (epithelioid subtype) was 50 years.The tumors were diffuse in 24 patients (96％) and localized in 1 patient (4％).Cytoreductive surgery was performed in 6 patients (24％),intraperitoneal chemotherapy in 12 patients (48％),and systemic chemotherapy in 24 patients (96％).The median overall survival was 26 months,with 1-year survival rate of 74.2％ and 5-year survival rate of 16.7％.Cytoreductive surgery or intraperitoneal chemotherapy combined with systemic chemotherapy showed a significant survival advantage over intraperitoneal or intravenous chemotherapy alone (P =0.046,P =0.005).Cytoreductive surgery (P =0.018) showed statistical significance by multivariate analysis as a predictive factor in survival (hazard rate =6.889;95％ CI =1.386-34.247).Conclusions MPM has its diverse clinical manifestations.Patients after cytoreductive surgery have longer survival time.Chemotherapy drugs (except for pemetrexed) and targeted therapy may be promising treatments.Cytoreductive surgery is an independent prognostic factor.关键词
恶性腹膜间皮瘤/诊断/治疗/预后Key words
malignant peritoneal mesothelioma/diagnosis/therapy/prognosis分类
医药卫生引用本文复制引用
李宁宁,白春梅,王颖轶,葛郁平,赵林..恶性腹膜间皮瘤25例临床分析[J].中国医学科学院学报,2018,40(2):211-218,8.
