中国医学科学院学报2018，Vol.40Issue(2)：242-249,8.DOI:10.3881/j.issn.1000-503X.2018.02.015
18氟-氟代脱氧葡萄糖正电子发射断层显像/磁共振成像与头颈部鳞癌病理分化的相关性及诊断价值
Correlations of 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging Parameters with the Pathological Differentiation of Head and Neck Squamous Cell Carcinoma and Their Diagnostic Efficiencies
摘要
Abstract
Objective To evaluate the correlation of the positron emission tomography/magnetic resonance imaging (PET/MR) parameters with the pathological differentiation of head and neck squamous cell carcinoma (HNSCC) and the diagnostic efficiencies of PET/MR parameters.Methods Patients with clinical suspicion of HNSCC were included and underwent PET/MR scan.HNSCC was pathologically confirmed in all these patients.The PET/MR examination included PET and MR sequences of diffusion-weighted imaging (DWI) and T2-and T1-weighted imaging.The multiple parameters of PET/MR included the mean values of apparent diffusion coefficient (ADCmean) and the maximum and mean values of standardized uptake value (SUVmax and SUVmean) were measured and estimated.The correlations of all the parameters and distribution between the different tumor differentiation groups were analyzed.Logistic regression was utilized to build the model as the PET/MR combined parameter for predicting the differentiation by multiple parameters of PET/MR.The receiver operating characteristic curve was calculated for each parameter and the combination.Results Totally 23 patients were included in this study:9 patients (9 males and 0 female) had well-differentiated tumor,with an average age of (61.0 ±6.8) years;14 cases had moderately-differentiated (n =10) or poorly-differentiated tumors (n =4),with an average age of (62.0 ± 9.1) years.All the patients were males.There was statistical correlation between SUV and SUVmax (P ＜ 0.001);however,ADC showed no statistical correlation with SUVmax and with SUVmean (P =0.42,P =0.13).ADCmean and SUVmean showed significant difference between well-differentiated group and moderately-poorly-differentiated group (P =0.005,P =0.007).Compared with the individual parameters,the combination of PET/MR parameters with SUVmean and ADCmean had higher efficacy in predicting tumor differentiation,with an area under curve of 0.84.Conclusions The distributions of ADCmean,SUVmax and SUVmean differ among HNSCC with different pathological differentiation.Compared with the individual parameters,the combination of the PET/MR parameters has higher efficiency in predicting tumor differentiation.关键词
正电子发射断层显像/磁共振成像/头颈部鳞状细胞癌/标准化摄取值/扩散加权成像/表观扩散系数/肿瘤病理分化Key words
positron emission tomography/magnetic resonance imaging/head and neck squamous cell carcinoma/standardized uptake value/diffusion-weighted imaging/apparent diffusion coefficient/tumor differentiation分类
医药卫生引用本文复制引用
党浩丹,金征宇,陈钰,师晓华,侯波,邢海群,张韬,陈兴明,张竹花,薛华丹..18氟-氟代脱氧葡萄糖正电子发射断层显像/磁共振成像与头颈部鳞癌病理分化的相关性及诊断价值[J].中国医学科学院学报,2018,40(2):242-249,8.基金项目
卫生公益性行业科研专项项目(201402019)和中央级公益性科研院所基本科研项目(2017PT32004)Supported by the Health Industry Special Scientific Research Project (201402019),and the National Public Welfare Basic Scientific Research Project (2017PT32004) （201402019）
