中华临床免疫和变态反应杂志2018，Vol.12Issue(1)：69-73,5.DOI:10.3969/j.issn.1673-8705.2018.01.016
肥大细胞在肺纤维化中的作用
Role of mast cells in the pathogenesis of pulmonary fibrosis
摘要
Abstract
Pulmonary fibrosis (PF) is one kind of chronic interstitial lung disease with poor prognosis.The average survival time for most patients was less than 5 years.The functions of mast cells (MCs) were varied,including the recruitment,activation,and differentiation of inflammatory cells,and the regulation of vascular permeability,smooth-muscle cell contractility,and fibroblast growth.It was shown that MCs were involved in the progression of fibrosis in different tissues and organs.Increasing activated MCs were observed in patients and animal models of PF.Mast cells appeared to be critical in the pathogenesis of pulmonary fibrosis by releasing a variety of cytokines.关键词
肺纤维化/肥大细胞Key words
pulmonary fibrosis/mast cells引用本文复制引用
卢慧,郭胤仕..肥大细胞在肺纤维化中的作用[J].中华临床免疫和变态反应杂志,2018,12(1):69-73,5.基金项目
国家卫生和计划生育委员会公益性行业科研专项(2015SQ00136)National Health and Family Planning Commission Public Welfare Research Project (2015SQ00136) （2015SQ00136）
