浙江医学2018，Vol.40Issue(5)：452-456,5.DOI:10.12056/j.issn.1006-2785.2018.40.5.2017-2372
TACE联合125I放射性粒子植入或三维适形放疗对肝细胞癌伴门静脉癌栓的疗效比较
Evaluation of transcather arterial chemoembolization combined with CT-guided 125I seed implantation or three-dimensional conformal radiotherapy in treatment of hepatocellular carcinoma with portal vein tumor thrombi
摘要
Abstract
Objective To compare the efficacy of transcather arterial chemoembolization (TACE) combined with CT-guided percutaneous 125 iodine (125I) seeds implantation or three-dimensional conformal radiotherapy (3DCRT) in treatment of advanced hepatocellular carcinoma (HCC) patients with portal vein tumor thrombi (PVTT).Methods Sixty-five HCC patients with PVTT were enrolled in this study,of whom 32 patients were received CT-guided implantation of 125I seeds (study group) and 33 patients were received 3DCRT (control group) after TACE procedure.The short-term efficacy (3 months after treatment),survival rate,length of hospitalization and overall costs were compared between two groups.Results The short-term efficacy rate in study group was significantly higher than that in control group (75.00％ vs 9.09％,P＜0.05).The 1-,2-and 3-year survival rates of study group were 53.1％,28.1％ and 12.5％ respectively,and those of control group were 30.3％,6.0％,0％ respectively.There was no significant difference in 1-year survival rate between the two groups (P ＞0.05);while the 2-year and 3-year survival rates of study group were higher than those in the control group(both P＜0.05).In addition,the length of hospital stay was shorter and the overall cost was lower in study group than those in control group (both P＜0.05).Conclusion The short-term efficacy and long-term survival of TACE combined implantation of 125I seeds are better and the length of hospital stay and overall cost are less than those of TACE combined with 3DCRT in treatment of advanced HCC patients with PVTT.关键词
肝细胞癌/门静脉癌栓/125I放射性粒子/3D适形放疗/肝动脉化疗栓塞Key words
Hepatocellular carcinoma/Portal vein tumor thrombosis/125I seeds/3DCRT/TACE引用本文复制引用
吴凡,郑家平,邵国良,罗君..TACE联合125I放射性粒子植入或三维适形放疗对肝细胞癌伴门静脉癌栓的疗效比较[J].浙江医学,2018,40(5):452-456,5.基金项目
浙江省医药卫生一般研究计划项目(2016KYA043),浙江省医药卫生一般研究计划项目(2013KYB041) （2016KYA043）
