浙江医学2018，Vol.40Issue(5)：465-467,后插1,4.DOI:10.12056/j.issn.1006-2785.2018.40.5.2017-2789
肝硬化大鼠ALPPS模型的建立
Establishment of ALPPS model in cirrhotic rats
摘要
Abstract
Objective To establish associating liver partition with portal vein ligation for staged hepatectomy (ALPPS)model in cirrhotic rats.Methods The rat cirrhosis induced by intraperitoneal injection of CCl4.After cirrhosis was established,the right lobe,caudate lobe,left lateral lobe and left inner lobe branches of portal veins were ligated,the middle lobe and papilla lobe branches of portal veins were retained.Liver partition was performed in the middle of right lobe and the left inner lobe.The survival of the animals more than 7 days after surgery was defined as success of the modeling.Results The average operative time of ALPPS was (26.75 ± 12.15) min.Forty out of the 50 rats survived for more than 7 days with a success rate of 80％.The causes of preoperative death mainly were anesthesia;those for intraoperative death were bleeding,perforation of diaphragm,inferior vena cava and hepatic vein injury;those for postoperative death were liver failure,biliary fistula and abdominal infection.Conclusion It is safe and feasible to establish the ALPPS model in rats with CCl4-induced cirrhosis.关键词
大鼠模型/肝硬化/联合门静脉结扎与原位肝脏劈离的二步肝切除术Key words
Rat model/Cirrhosis/ALPPS引用本文复制引用
肖遵强,黄静,于茜,张孔亮,熊超杰,陆才德..肝硬化大鼠ALPPS模型的建立[J].浙江医学,2018,40(5):465-467,后插1,4.基金项目
宁波市医学科技计划项目(2014A02) （2014A02）
