浙江医学2018，Vol.40Issue(5)：471-474,478,5.DOI:10.12056/j.issn.1006-2785.2018.40.5.2017-1025
不同促排卵方案中雌激素和孕激素对妊娠结局的影响研究
Serum estradiol, progesterone levels and pregnancy outcomes in different stimulating ovulation protocols
摘要
Abstract
Objective To investigate the estradiol (E2),progesterone (P) levels and progesterone/estradio (P/E2) ratio in different stimulating ovulation protocols and the correlation with pregnancy outcomes.Methods Sixty-six infertility women with 80 stimulating ovulation cycles were recruited in the study,including 19 cases (24 cycles) using clomiphene citrate for stimulating (CC group),17 cases (23 cycles) using CC+menotrophin injection (CC+HMG group),18 cases (20 cycles) using HMG (HMG group),and 10 cases (13 cycles) using letrozole (LE group).The pregnancy rates were documented and compared among 4 groups.The E2,P levels and P/E2 ratio at HCG day were measured and compared among 4 groups and between pregnant and non-pregnant groups.Results The pregnancy rates in HMG and CC+HMC groups were significantly higher than that in CC group (47.1％,44.7％ vs.10.5％,P＜0.05).There were significant differences in serum E2 levels at HCG day among different groups (all P＜0.05).Compared to CC group,the serum P levels at HCG day were significantly higher in CC+HMG,HMG and LE groups (all P＜0.05),while the level in CC+HMG group was higher than that in HMG group (P＜0.05).The P/E2 ratios in CC,CC+HMG and HMG groups were significantly different to that in LE group,(all P＜0.05).There was no statistically significant difference in the serum E2,P levels and P/E2 at HCG day between pregnant and non-pregnant women (all P ＞0.05).Conclusion HMG protocol may produce better E2 and P levels in stimulating ovulation,which are beneficial for the embryo development and endometrial receptivity leading to the success of pregnancy.关键词
促排卵/雌激素/孕激素/子宫内膜容受性/胚胎着床Key words
Ovulation induction/Estradiol/Progesterone/Endometrial receptivity/Embryo implantation引用本文复制引用
马林,黄坚,张治芬..不同促排卵方案中雌激素和孕激素对妊娠结局的影响研究[J].浙江医学,2018,40(5):471-474,478,5.基金项目
杭州市卫生科技计划项目(2012A014) （2012A014）
