浙江医学2018，Vol.40Issue(5)：479-481,491,4.DOI:10.12056/j.issn.1006-2785.2018.40.5.2017-800
功能性脾动脉栓塞术与经颈静脉肝内门体分流术对PLT减少肝硬化患者外周血细胞变化的影响研究
Long-term effect of functional splenic artery embolization and transjugular intrahepatic portosystemic shunt on blood cell counts in cirrhotic patients with thrombocytopenia
摘要
Abstract
Objective To investigate the effect of functional splenic artery embolization(FSE) and intrahepatic portal shunt (TIPS) on peripheral blood cell counts in patients with thrombocytopenia.Methods Fifty cirrhotic patients with thrombocytopenia admitted from December 2013 to December 2015 were enrolled in the study.Among 50 patients 30 were treated with simple TIPS (TIPS group),and 20 were treated with TIPS and followed FSE surgery (TIPS + FSE group).The peripheral blood cell counts were measured at 3d before surgery,3d and 3,6 months and 1 year after surgery,the complications were also documented in two groups.The factors related to the increase of PLT after FSE were also analyzed.Results The platelet (PLT) count in TIPS + FSE group was higher than that in TIPS group 6 months and 1 year after surgery (all P＜0.05),while there were no statistically significant differences in white blood cell (WBC) count and hemoglobin values (all P ＞0.05) between two groups.There was no significant difference in the incidence of mild and severe complications between TIPS group and the TIPS + FSE group.Correlation analysis showed that age,preoperative PLT count,preoperative thrombocytocrit and preoperative PLT to large cell ratio were predicting factors for the increase of PLT 1 year after FSE (all P＜0.05).Conclusion TIPS and FSE provide a stable long-term effect of platelet increase,a decreased needs of platelet transfusion and hospitalization for cirrhotic patients with thrombocytopenia.关键词
功能性脾动脉栓塞术/经颈静脉肝内门体分流术/肝硬化/PLT减少Key words
Functional splenic artery embolization/Transjugular intrahepaticportosystemic shunt/Cirrhosis/Thrombocytopenia引用本文复制引用
陈旭艳,陈仁聘,吴建胜,黄智铭,吴伟..功能性脾动脉栓塞术与经颈静脉肝内门体分流术对PLT减少肝硬化患者外周血细胞变化的影响研究[J].浙江医学,2018,40(5):479-481,491,4.基金项目
浙江省科技计划项目(2015C33120) （2015C33120）
