浙江医学2018，Vol.40Issue(6)：560-563,4.DOI:10.12056/j.issn.1006-2785.2018.40.6.2017-2219
miR-340在膀胱尿路上皮癌中的表达及其靶基因预测的生物信息学分析
Expression of miR-340 in bladder urothelial carcinoma and bioinformatically analysis of its target genes
摘要
Abstract
Objective To investigate the expression of miR-340 in bladder urothelial carcinoma,and to analyze the target genes of miR-340 with bioinformatics.Methods miRNA array was applied to detect miRNA expression profile in bladder urothelial carcinoma,and qRT-PCR was used for validation.The bioinformatic analysis of the target genes of miR-340,the involved gene ontology and signal transduction pathway was performed.Results The expression of miR340 significantly decreased in bladder urothelial cancer compared with that normal bladder urothelial tissues.The functions of predicted target genes of miR-340 were enriched in cell adhesion,biological adhesion and cell-cell adhesion.KEGG pathway analysis showed the the predicted target genes were involved in pathways of cancer and cell cycle.Conclusion The expression of miR-340 significantly decreases in bladder urothelial carcinoma;and the predicted target genes of miR-340 are significantly enriched in tumor related signaling pathways.关键词
miR-340/膀胱肿瘤/靶基因/生物信息学Key words
miR-340/Bladder cancer/Target gene/Bioformatics引用本文复制引用
潘寿华,朱智荣..miR-340在膀胱尿路上皮癌中的表达及其靶基因预测的生物信息学分析[J].浙江医学,2018,40(6):560-563,4.基金项目
浙江省医药卫生科技计划(2017ky152) （2017ky152）
