浙江医学2018，Vol.40Issue(6)：564-567,4.DOI:10.12056/j.issn.1006-2785.2018.40.6.2017-1456
ApoE基因多态性与脑电图慢波的关联性研究
Association between ApoE gene polymorphism and slow waves of electroencephalogram
摘要
Abstract
Objective To study the distribution of ApoE gene polymorphism and its relation to slow waves of electroencephalogram.Methods Patients with Mini Mental State Examination (MMSE) ＞24 and no cerebral infarction history were examined by electroencephalogram.Those with slow waves in electroencephalogram were recruited in the research group and the healthy controls were also recruited.The ApoE gene polymorphism was determined by PCR method in two group.The association of ApoE gene polymorphism with the onset age of slow waves in research group was analyzed.Results The research group had significantly higher ε4 genotype frequency (51.78％,58/112) and ε4 allele frequency (36.16％,81/224) as compared to those of the control group (16.08％,18/112 and 10.71％,24/224) (both P=0.000).ApoE ε2 and ε3 genotype frequency (11.61％,13/112 and 36.61％,41/112) and allele frequency (9.38％,21/224 and 54.46％,122/224) were significant lower in the research group as compared with those in the control group (P=0.02,0.000,0.002 and 0.001).Patients with ε 4 genotype had a significantly younger onset age of slow waves (64.07 ± 5.57 years) as compared to ε 2 genotype (70.69 ± 8.29 years) (P=0.000) and ε 3 genotype (67.73 ±6.10 years) (P=0.003).Conclusion ApoE ε 4 genotype is associated with slow waves of electroencephalogram and it is also related to early onset of slow waves than other genotypes.关键词
载脂蛋白E基因多态性/脑电图/慢波/始发年龄Key words
Apolipoprotein genetic polymorphism/Electroencephalogram/Slow waves/Onset age引用本文复制引用
罗伏钢,李静,陈梅芳,迟淑梅,宋明芬..ApoE基因多态性与脑电图慢波的关联性研究[J].浙江医学,2018,40(6):564-567,4.基金项目
国家自然科学基金(81601183) （81601183）
杭州市科技发展计划项目重点专科专病科研攻关专项(20150633B10,20160533B28) （20150633B10,20160533B28）
