浙江医学2018，Vol.40Issue(6)：582-585,4.DOI:10.12056/j.issn.1006-2785.2018.40.6.2017-3036
ICU获得性肌无力的高危因素分析及其对预后的影响
Risk factors of ICU-acquired muscle weakness
摘要
Abstract
Objective To investigate the risk factors of ICU-acquired muscle weakness.Methods Total 491 patients admitted in general ICU or emergency ICU were enrolled in this study,among whom ICU-acquired muscle weakness developed in 260 patients (muscle weakness group) and patients without muscle weakness served as the control group (n=231).The age,sex,hyperthermia,shock index,APACHEII score,severe sepsis,multiple organ dysfunction,hypoxemia,anemia,acute renal injury,plasma hyperosmosis,hypoproteinemia,hyperglycemia total intravenous nutrition,the application of vasoactive drugs,sedatives,hormones,neuromuscular blockers,braking,mechanical ventilation time,ICU stay were compared between the two groups.Binary logistic regression analysis was employed to assess the risk factors of ICU-acquired muscle weakness,and the impact of iatrogenic risk factors on prognosis of patients with ICU-acquired myasthenia gravis was also analyzed.Results Logistic regression analysis showed that age,shock,APACHE Ⅱ score,severe sepsis,multiple organ dysfunction,acute kidney injury,plasma hyperosmosis,hyperglycemia,total intravenous nutrition,sedatives,neuromuscular blockers,movement restraining,mechanical ventilation time,ICU time were the risk factors for ICU-acquired muscle weakness.The administration of neuromuscular blockers benefited the prognosis of patients.Conclusion The causes of ICU-acquired muscle weakness are complex;it is recommended to take comprehensive prevention and control measures for high-risk patients.Neuromuscular blockers benefited the prognosis of patients with ICU-acquired muscle weakness.关键词
ICU/ICU获得性肌无力/高危因素/神经肌肉阻滞剂Key words
Intensive care unit/ICU-acquired muscle weakness/Risk factors/Neuromuscular blockers引用本文复制引用
陈新国,徐建国..ICU获得性肌无力的高危因素分析及其对预后的影响[J].浙江医学,2018,40(6):582-585,4.基金项目
温州市人民医院院内资助项目(2015007) （2015007）
