浙江医学2018，Vol.40Issue(6)：627-630,4.DOI:10.12056/j.issn.1006-2785.2018.40.6.2017-1902
中晚期孕妇血清25-羟维生素D与骨代谢标志物水平及关系
Relationships of serum 25-hydroxyvitamin D levels with bone metabolism markers in the second and third trimester of pregnant women
孙红 1陈士华 2王良平 2郑晓群2
作者信息
- 1. 325000 温州医科大学检验医学院
- 2. 平湖市第一人民医院检验科
- 折叠
摘要
Abstract
Objective To investigate the relationships of serum 25-hydroxyvitamin D levels with bone metabolism markers in the second and third trimester of pregnancy women.Methods A total of 1090 pregnant women(13-40 weeks gestational age) and 120 healthy nulliparous were enrolled.The levels of serum 25 (OH)D,N-MID,β-CTX were determined by electrochemical luminescence.Results The average serum 25 (OH)D level was (11.23 ± 5.82)ng/ml in the second and third trimester of pregnancy.There 917 cases (84.13％) with 25(OH)D deficiency,152 cases (13.94％) with insufficiency and 21 cases (1.93％) with sufficiency.The serum 25(OH)D level in winter and spring was lower than that in summer and autumn (9.97 ± 5.28 ng/ml vs.12.24 ± 5.77 ng/ml,P＜0.05).There were significant differences in serum 25 (OH)D,N-MID and β-CTX levels among pregnant women in different age groups (P＜0.05).The level of Vitamin D was not correlated with N-MID(r=-0.017,P ＞0.05),negatively correlated with β-CTX (r=-0.090,P＜0.05);and N-MID was positively correlated with β-CTX (r=0.586,P＜0.05).Conclusion Vitamin D deficiency is common during the second and third trimester of pregnant women,particularly in winter and spring seasons.The serum 25(OH)D and N-MID,β-CTX levels are different in pregnant women of different ages.The level of serum 25 (OH)D shows no significant correlation with N-MID but negative correlation with β-CTX.关键词
妊娠/25-羟维生素D/N-端骨钙素/β-胶原特殊序列Key words
Pregnant/25-hydroxyvitamin D/N-MID/β-CTX引用本文复制引用
孙红,陈士华,王良平,郑晓群..中晚期孕妇血清25-羟维生素D与骨代谢标志物水平及关系[J].浙江医学,2018,40(6):627-630,4.
