浙江医学2018，Vol.40Issue(6)：631-634,642,5.DOI:10.12056/j.issn.1006-2785.2018.40.6.2017-2168
血清淀粉样蛋白A、触珠蛋白水平与急性脑梗死患者预后的相关性
Correlation of serum amyloid A (SAA)and haptoglobin levels with prognosis of acute cerebral infarction
魏婉 1缪卫琴 1蒋敏海1
作者信息
- 1. 310006 杭州市第一人民医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the correlation of serum amyloid A (SAA) and hptoglobin levels with the prognosis of acute cerebral infarction.Methods Six hundred and one patients with acute cerebral infarction admitted in the Department of Neurology,Hangzhou First People's Hospital from January 2016 to April 2017 were enrolled in the study.The levels of SAA and haptoglobin in serum were measured by dual-ray immunoturbidimetry.The National Institutes of Health Stroke Scale(NIHSS) was used to assess the severity of prognosis 2 weeks after admission.Pearson correlation analysis was performed to determine the correlation between serum SAA,haptoglobin levels and the severity of prognosis in patients.All patients were followed up for 3 months after discharge and assessed with a modified Rankin scale (mRS).Univariate analysis and multivariate logistic regression analyses were used to analyze the prognostic factors of acute cerebral infarction for 3 months.Results In 601 patients there were 451 mild cases,130 moderate cases and 20 severe cases.The levels of serum SAA and haptoglobin in severe group [(85.90 ± 64.56)mg/L and(1 860.00 ± 91.59)mg/L)] were higher than those in moderate [(31.75 ± 47.39)mg/L and(1 431.55 ± 89.45) mg/L]and mild group [(18.56 ± 33.60)mg/L and (1 262.72 ± 82.57)mg/L)],while the levels in moderate group were higher than those in mild group [(F=33.320 and 4.532,both P＜0.05)].Pearson analysis showed that the serum SAA and haptoglobin levels were positively correlated with the severity of the prognosis of acute cerebral infarction after 2 weeks (r =0.282,r =0.137,P＜ 0.05).After following up for 3 months,there were 490 patients with good outcome and 111 patients with poor outcome.Multivariate logistic regression analysis showed that SAA and age were independent risk factors for poor outcome of acute cerebral infarction (P＜0.05).Conclusion The Serum of SAA and haptoglobin levels are correlated with the severity of acute cerebral infarction,and serum SAA level is an independent risk factor for poor outcome of patients with acute cerebral infarction.关键词
急性脑梗死/血清淀粉样蛋白A/触珠蛋白/预后Key words
Acute cerebral infarction/Serum amyloid A/Haptoglobin/Prognosis引用本文复制引用
魏婉,缪卫琴,蒋敏海..血清淀粉样蛋白A、触珠蛋白水平与急性脑梗死患者预后的相关性[J].浙江医学,2018,40(6):631-634,642,5.
