浙江医学2018，Vol.40Issue(7)：669-675,7.DOI:10.12056/j.issn.1006-2785.2018.40.7.2017-1557
对氧磷酶1基因多态性与乳腺癌的相关性研究
Association of paraoxonase 1 gene polymorphism with breast cancer
摘要
Abstract
Objective To study the association between the polymorphism of L55M and Q192R in paraoxonase 1 (PON1) gene and the risk of breast cancer.Methods A total of 260 patients with breast cancer were enrolled as the study group from January 2010 to April 2015;260 healthy women were recruited as the control group.Genomic DNA was extracted from the peripheral blood samples of all subjects.The polymorphisms of PON1 gene L55M and Q192R were analyzed and the relationship between the frequency of L55M and Q192R polymorphisms of PON1 gene and the clinicopathological parameters of breast cancer patients was analyzed.Results There was significant difference in polymorphisms of L55M genotype and allele frequency between study group and control group(all P＜0.05).The LM,MM and LM+MM genotypes or M allele were associated with the breast cancer (all P＜0.05).There was no significant difference in Q192R polymorphisms between the study group and the control group (all P ＞0.05).The QR,RR,QR+RR genotypes or R allele were not associated with the breast cancer (all P ＞ 0.05).Patients with breast cancer carrying M alleles in L55M were more likely to have lymph node metastasis before and after menopause (both P＜0.05),while there was no significant association between the mutations at the Q192R locus and the clinicopathological parameters (all P ＞0.05).Conclusion The L55M polymorphism of PON1 gene may be associated with the risk of breast cancer and the gene locus might be used as a genetic marker for the prognosis of breast cancer.women.关键词
对氧磷酶1/乳腺癌/基因突变/单核苷酸多态性Key words
Paraoxonase 1/Breast cancer/Gene mutation/Single nucleotide polymorphism引用本文复制引用
傅春燕,程雪,潘颖,陈述政,徐民..对氧磷酶1基因多态性与乳腺癌的相关性研究[J].浙江医学,2018,40(7):669-675,7.基金项目
浙江省医药卫生科技计划项目(2016KYA201) （2016KYA201）
丽水市科技局项目(2016zdxk01) （2016zdxk01）
