浙江医学2018，Vol.40Issue(7)：684-687,692,5.DOI:10.12056/j.issn.1006-2785.2018.40.7.2017-624
HPV E6/E7mRNA检测对绝经后妇女宫颈病变诊断的价值
Diagnostic value of HPV E6/E7 mRNA test for cervical lesions in postmenopausal women
摘要
Abstract
Objective To assess the value of HPV E6/E7 mRNA test for diagnosis of cervical lesions in postmenopausal women.Methods A total of 1 032 postmenopausal women who were screened by Thinprep cytologic test(TCT) and HR-HPV DNA in Quzhou People's Hospital from February 2015 to February 2017 were enrolled.Patients with either positive results were referred to HPV E6/E7 mRNA test and colposcopic examination.With the pathological results as the gold standard,the value of HPV E6/E7 mRNA test in diagnosis of above high-grade squamous intraepithelial lesions (HSIL+) was evaluated and compared with the TCT and HR-HPV DNA test;the expression of HPV E6/E7 mRNA in different cervical lesions was also compared.Results The sensitivity,specificity,positive predictive value and negative predictive value of TCT for diagnosis of HSIL+ were all lower than those of HPV E6/E7 mRNA(all P＜0.05).There were no statistically significant difference in sensitivity,positive predictive value and negative predictive value for diagnosis of HSIL+ between HR-HPV DNA and HPV E6/E7 mRNA(all P＞0.05),but the specificity of HR-HPV DNA was significantly lower than that of HPV E6/E7 mRNA test (P＜0.01).Among three test methods,the specificity of HPV E6/E7 mRNA was the highest.There was significant difference in the expression levels of HPV E6/E7 mRNA among patients with different pathological grades (P＜0.01).A positive correlation was found between the pathological grades and the expression of HPV E6/E7 mRNA(r =0.401,P＜0.01).Conclusion HPV E6/E7 mRNA test is of clinical value in screening cervical cancer and predicting the risk of HSIL+ in postmenopausal women.关键词
HPV E6/E7 mRNA/TCT/HR-HPV DNA/绝经后妇女/宫颈病变Key words
HPV E6/E7 mRNA/TCT/HR-HPV DNA/Postmenopausal women/Cervical lesions引用本文复制引用
王静,徐小敏,兰香,周燕..HPV E6/E7mRNA检测对绝经后妇女宫颈病变诊断的价值[J].浙江医学,2018,40(7):684-687,692,5.基金项目
衢州市指导性科技项目(2016072) （2016072）
