浙江医学2018，Vol.40Issue(7)：725-728,4.DOI:10.12056/j.issn.1006-2785.2018.40.7.2017-1404
阿托西班治疗晚期流产及先兆早产的疗效观察
Atosiban in the treatment of threatened late abortion and preterm labor
金利栩 1舒丹桦 1吴乐 1肖碧如 1王海欧 1包影 1张文淼1
作者信息
- 1. 325000 温州医科大学附属第一医院产科
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of oxytocin antagonist atosiban in preventing late abortion,preterm labour,placenta previa and cervical incompetence.Methods Fifty five pregnant women receiving the treatment with atosiban in our hospital were recruited in this study.Among 55 cases,there were 43 cases of threatened late abortion or preterm labor,8 cases of placenta previa,and 4 cases of cervical incompetence.Clinical data were collected,including the effectiveness of prolonging delivery over 48h or 7d;prolonged gestational days;drug adverse reaction;pregnancy outcome,term delivery or delivery up to expectations and perinatal outcome.In the group of threatened late abortion or preterm labor,Kaplan-Meier was used to analyze the correlation of pregnant outcomes with different variables:age ＜30 or ≥30 years,multipara or primipara,singleton pregnancy or multiple pregnancy,＜28 or ≥28 weeks at the time of receiving atosiban.Results There were significant differences in prolonged gestational days,gestational age and term delivery rate among three groups (all P＜0.05);there indicators in cervical incompetence group were significantly higher than those in other two groups (all P＜0.05).The gestational age at delivery was longer than that at the time of receiving atosiban in late abortion or preterm labor group and cervical incompetence group (both P＜0.05),but there was no difference in placenta previa group(P ＞0.05).In the group of threatened late abortion or preterm labor,there were no significant differences in pregnancy outcome among those ＜30 or ≥30 years old,multipara or primipara,singleton pregnancy or multiple pregnancy and ＜28 or ≥28 weeks at the time of receiving atosiban (all P ＞0.05).Conclusion The use of atosiban can effectively prolong the gestational time of patient with cervical incompetence.The sequential treatment of atosiban and ritodrine is available for patients with different ages,number of pregnancies,gestational age or fetal numbers.关键词
晚期流产/先兆早产/阿托西班Key words
Threatened late abortion/Threatened preterm labor/Atosiban引用本文复制引用
金利栩,舒丹桦,吴乐,肖碧如,王海欧,包影,张文淼..阿托西班治疗晚期流产及先兆早产的疗效观察[J].浙江医学,2018,40(7):725-728,4.
