浙江医学2018，Vol.40Issue(7)：729-731,后插2,4.DOI:10.12056/j.issn.1006-2785.2018.40.7.2017-1218
苍南地区前列腺癌与HPV16/18感染的相关性研究
Association between HPV16/18 infection and prostate cancer in Cangnan
摘要
Abstract
Objective TO investigate the association between high-risk human papilloma virus (HPV16/18) infection and prostate cancer (PCa) in Cangnan.Methods 64 PCa patients and 72 patients with benign prostatic hyperplasia (BPH) were enrolled from 2012 to 2016.HPV16/18 infection was detected by hybridization in situ in paraffin-embedded specimens,and the expression of p16 was detected by immunohistochemical En Vision method.High risk HPV testing was performed by hybridcapture method in urine samples collected from patients in 2016.The biopsy specimens were examined by electron microscopy.Results The positive rates of HPV16/18 and expression p16 in PCa tissue were significantly higher than those in the BPH group (both P＜ 0.01).There was significant difference in the positive rate of high-risk HPV between the urine samples from two groups (P＜ 0.05).Virus-like particles were observed in 4 of 10 PCa biopsy specimens under electron microscopy,and no virus-like particles were found in 7 BPH specimens.Conclusion The results indicate that prostate cancer may be associated with HPV16/18 infection in Cangnan.关键词
前列腺癌/良性前列腺增生/高危型人乳头瘤病毒/尿液/电镜Key words
Prostate cancer/Benign prostatic hyperplasia/High-risk human papillomavirus/Urine/Electron microscope引用本文复制引用
黄兆浪,庄小艺,周炳同,温莉虹..苍南地区前列腺癌与HPV16/18感染的相关性研究[J].浙江医学,2018,40(7):729-731,后插2,4.基金项目
温州市公益性社会发展(医疗卫生)科技项目(Y20160189) （医疗卫生）
