浙江医学2018，Vol.40Issue(8)：824-827,832,后插4,6.DOI:10.12056/j.issn.1006-2785.2017.40.8.2017-2927
锁骨上淋巴结转移对N3-ⅢB期非小细胞肺癌根治性放化疗的预后意义
Supraclavicular lymph node metastasis is not correlated with the prognosis of N3-stage Ⅲ B non-small cell lung cancer patients with chemoradiotherapy
摘要
Abstract
Objective To investigate the prognostic significance of supraclavicular lymph node (SCLN) in patients with N3-Ⅲ B non-small cell lung cancer (NSCLC) treated with chemoradiotherapy.Methods Two hundred and forty-five patients with N3-Ⅲ B NSCLC who were treated with radical chemoradiotherapy were enrolled,including 117 cases with positive supraclavicular lymph node (SCLN+ group) and 128 cases of negative SCLN (SCLN-group).The overall survival (OS) and progressive free survival(PFS) were analyzed with Kaplan-Meier method.Cox regression for multivariate analysis were performed to determine the effect of several potential confounding variables.Results The median OS and PFS were 19(10,31) months and 10 (7,16) months in these patients.There were no significant difference in OS and PFS between SCLN+ and SCLN-groups (P ＞ 0.05).The OS was not statistically different between the pathologically and clinically SCLN+ subgroups (P ＞0.05).Multivariate analysis showed that SCLN metastasis was not a significant factor for OS and PFS (all P ＞0.05).Primary tumor location and concurrent chemoradiotherapy were the independent prognosis factors for OS (all P＜0.05).Age less than 60,primary tumor location and concurrent chemoradiotherapy were associated with a favorable PFS (all P ＜0.05).The difference of distant metastasis rate between SCLN+ and SCLN-groups was not significant(P＞0.05).Conclusion When treated with chemoradiotherapy,the outcomes for patients appear to be not correlated with SCLN metastasis in patients with N3-Ⅲ B NSCLC.关键词
锁骨上淋巴结/非小细胞肺癌/根治性放化疗/预后Key words
Supraclavicular lymph node/Non-small cell lung cancer/Chemoradiotherapy/Prognosis引用本文复制引用
胡静,郑璐,张欢乐,丁祺,陆妙珍,徐国栋,李旎..锁骨上淋巴结转移对N3-ⅢB期非小细胞肺癌根治性放化疗的预后意义[J].浙江医学,2018,40(8):824-827,832,后插4,6.基金项目
浙江省自然科学基金项目(LQ16H160002) （LQ16H160002）
